{"id":79122,"date":"2018-03-09T23:24:54","date_gmt":"2018-03-09T23:24:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regioselectividad-en-acoplamientos-cruzados-catalizados-por-paladio-de-24-dibromopiridina-sa%c2%adntesis-estereoselectiva-del-pigmento-ocular-a2e\/"},"modified":"2018-03-09T23:24:54","modified_gmt":"2018-03-09T23:24:54","slug":"regioselectividad-en-acoplamientos-cruzados-catalizados-por-paladio-de-24-dibromopiridina-sa%c2%adntesis-estereoselectiva-del-pigmento-ocular-a2e","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/mecanismos-de-las-reacciones-organicas\/regioselectividad-en-acoplamientos-cruzados-catalizados-por-paladio-de-24-dibromopiridina-sa%c2%adntesis-estereoselectiva-del-pigmento-ocular-a2e\/","title":{"rendered":"Regioselectividad en acoplamientos cruzados catalizados por paladio de 2,4-dibromopiridina. s\u00edntesis estereoselectiva del pigmento ocular a2e"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Sicre Gonz\u00e1lez <\/strong><\/h2>\n<p>El objetivo de este trabajo consist\u00eda en la s\u00edntesis estereocontrolada del pigmento a2e, un compuesto pirid\u00ednico 2,4-disustituido poli\u00e9nico que posee una porci\u00f3n com\u00fan en ambas cadenas, cuya acumulaci\u00f3n est\u00e1 relacionada con la degeneraci\u00f3n macular asociada a la edad (amd).     para ello se ha desarrollado una estrategia basada en la formaci\u00f3n de enlaces sencillos c-c empleando reacciones de acoplamiento cruzado catalizados por paladio. As\u00ed, mediante dos acoplamientos sucesivos sobre las posiciones 2 y 4 de 2,4-dibrompiridina, seguida dela funcionalizaci\u00f3n de las cadenas como bisalquenilestannaras y posterior doble acoplamiento estereoselectivo con un yoduro trien\u00edlico que conten\u00eda la porci\u00f3n com\u00fan, se obtuvo el pigmento a2e en 8 pasos con un rendimiento global del 14%.     paralelamente se ha llevado a cabo un estudio de la regioselectividad en el acoplamiento de 2,4-dibromopindina y diferentes derivados organomet\u00e1licos en las condiciones de stille, suzuki y sonogashira, junto con un estudio mecan\u00edstico de la reacci\u00f3n de suzuki entre 2,4-dibromapiridina y \u00e1cido jenilbo\u00edonico empleando t\u00e9cnicas de rmn de 31p y 1h.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regioselectividad en acoplamientos cruzados catalizados por paladio de 2,4-dibromopiridina. s\u00edntesis estereoselectiva del pigmento ocular a2e<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regioselectividad en acoplamientos cruzados catalizados por paladio de 2,4-dibromopiridina. s\u00edntesis estereoselectiva del pigmento ocular a2e <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Sicre Gonz\u00e1lez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Vigo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/03\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Cid Fern\u00e1ndez M. Magdalena<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Suau suarez <\/li>\n<li>dolores P\u00e9rez meir\u00e1s (vocal)<\/li>\n<li>carmen N\u00e1jera domingo (vocal)<\/li>\n<li>eva Codesido varela (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Sicre Gonz\u00e1lez El objetivo de este trabajo consist\u00eda en la s\u00edntesis estereocontrolada del pigmento a2e, un [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1412,239,6775,18657],"tags":[19243,119913,169904,169905,169906,2512],"class_list":["post-79122","post","type-post","status-publish","format-standard","hentry","category-compuestos-heterociclicos","category-mecanismos-de-las-reacciones-organicas","category-organometalicos","category-vigo","tag-carmen-najera-domingo","tag-cid-fernandez-m-magdalena","tag-cristina-sicre-gonzalez","tag-dolores-perez-meiras","tag-eva-codesido-varela","tag-rafael-suau-suarez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79122","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=79122"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79122\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=79122"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=79122"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=79122"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}