{"id":79154,"date":"2018-03-09T23:24:58","date_gmt":"2018-03-09T23:24:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-adiponectina-en-musculo-esqueletico-y-sus-efectos-en-la-resistencia-a-insulina-y-la-obesidad\/"},"modified":"2018-03-09T23:24:58","modified_gmt":"2018-03-09T23:24:58","slug":"expresion-de-adiponectina-en-musculo-esqueletico-y-sus-efectos-en-la-resistencia-a-insulina-y-la-obesidad","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/expresion-de-adiponectina-en-musculo-esqueletico-y-sus-efectos-en-la-resistencia-a-insulina-y-la-obesidad\/","title":{"rendered":"Expresi\u00f3n de adiponectina en m\u00fasculo esquel\u00e9tico y sus efectos en la resistencia a insulina y la obesidad"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Hidalgo Barrera <\/strong><\/h2>\n<p>La adiponectina es una dipoquina cuyos mecanismos de actuaci\u00f3n no se conocen todav\u00eda con exactitud. Niveles plasm\u00e1ticos bajos de adiponectina se han correlacionado con la obesidad y con la resistencia a insulina y la hiperinsulinemia incluso en individuos no obesos.  la adiponectina promueve la sensibilidad a insulina y protege de la obesidad y, por tanto, se ha sugerido que podr\u00eda ser utilizada para mejorar la sensibilidad a insulina en pacientes diab\u00e9ticos y obesos. El incremento de la oxidaci\u00f3n de l\u00edpidos en m\u00fasculo esquel\u00e9tico mediado por la adiponectina se ha considerado como uno de los principales factores que conduce a la mejora en la se\u00f1alizaci\u00f3n y la sensibilidad a insulina a nivel sist\u00e9mico. Estos datos suger\u00edan que la expresi\u00f3n constitutiva de adiponectina en m\u00fasculo esquel\u00e9tico y sus efectos en este tejido podr\u00edan proteger de la resistencia a insulina y la obesidad inducida por una dieta alta en l\u00edpidos.  en la primera parte del presente estudio, se analizaron los efectos de la expresi\u00f3n de adiponectina en m\u00fasculo esquel\u00e9tico en la sensibilidad a insulina y la obesidad. Con este fin, se generaron ratones transg\u00e9nicos que expresaban adiponectina localmente en m\u00fasculo esquel\u00e9tico. Estos animales se alimentaron con una dieta alta en l\u00edpidos. De la misma manera, se expres\u00f3 adiponectina en m\u00fasculo esquel\u00e9tico en ratones mediante la utilizaci\u00f3n de vectores virales. Posteriormente, estos animales tambi\u00e9n se alimentaron con dieta alta en l\u00edpidos para valorar el efecto de la expresi\u00f3n de adiponectina en la sensiblidad a insulina y la obesidad.  se observ\u00f3 que la adiponectina actuaba a nivel local en el m\u00fasculo esquel\u00e9tico aumentando la sensibilidad a insulina en condiciones est\u00e1ndar de alimentaci\u00f3n a la vez que induc\u00eda una mayor predisposici\u00f3n a oxidar \u00e1cidos grasos en este tejido. Sin embargo, este efecto de la adiponectina exclusivamente en m\u00fasculo esquel\u00e9tico no era suficiente para contrarr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n de adiponectina en m\u00fasculo esquel\u00e9tico y sus efectos en la resistencia a insulina y la obesidad<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n de adiponectina en m\u00fasculo esquel\u00e9tico y sus efectos en la resistencia a insulina y la obesidad <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Hidalgo Barrera <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/03\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fatima Bosch Tubert<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  emilio Feliu albi\u00f1ana <\/li>\n<li> Fern\u00e1ndez real Jos\u00e9 Manuel (vocal)<\/li>\n<li>sylvie Franckhauser (vocal)<\/li>\n<li>malcolm Watford (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Hidalgo Barrera La adiponectina es una dipoquina cuyos mecanismos de actuaci\u00f3n no se conocen todav\u00eda con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,13696,258,17],"tags":[169972,14073,122105,14572,169974,169973],"class_list":["post-79154","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-glucidos","category-hormonas","category-quimica","tag-antonio-hidalgo-barrera","tag-fatima-bosch-tubert","tag-fernandez-real-jose-manuel","tag-juan-emilio-feliu-albinana","tag-malcolm-watford","tag-sylvie-franckhauser"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79154","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=79154"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79154\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=79154"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=79154"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=79154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}