{"id":79168,"date":"2018-03-09T23:24:58","date_gmt":"2018-03-09T23:24:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/variantes-polimorficas-del-gen-del-receptor-de-la-vitamina-d-vdr-efecto-sobre-la-regulacion-del-metabolismo-del-hueso-y-de-la-glndula-paratiroides\/"},"modified":"2018-03-09T23:24:58","modified_gmt":"2018-03-09T23:24:58","slug":"variantes-polimorficas-del-gen-del-receptor-de-la-vitamina-d-vdr-efecto-sobre-la-regulacion-del-metabolismo-del-hueso-y-de-la-glndula-paratiroides","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/variantes-polimorficas-del-gen-del-receptor-de-la-vitamina-d-vdr-efecto-sobre-la-regulacion-del-metabolismo-del-hueso-y-de-la-glndula-paratiroides\/","title":{"rendered":"Variantes  polimorficas del gen del receptor de la vitamina d (vdr). efecto sobre la regulacion del metabolismo del hueso y de la glndula paratiroides."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Daniel Serafin Alvarez Hernandez <\/strong><\/h2>\n<p>El objetivo general de la tesis doctoral fue determinar la influencia de diferentes polimorfismos del gen del receptor de la vitamina d (vdr) y del col\u00e1geno tipo i (colia1) sobre diferentes aspectos relacionados con el metabolismo del hueso y de la gl\u00e1ndula paratiroides, realizando dos grupos de estudios claramente diferenciados: estudios epidemiol\u00f3gicos y estudios experimentales.  los estudios epidemiol\u00f3gicos, realizados en poblaci\u00f3n no seleccionada de ambos sexos, mostraron que mientras que en mujeres s\u00f3lo el polimorfismo sp1 del colia1 fue marcador de la presencia de fracturas osteopor\u00f3ticas, en los hombres los polimorfismos bsmi, apai y taqi del vdr agrupados en haplotipos y el sp1 del colia1 fueron predictores del riesgo de fracturas osteopor\u00f3ticas.  en los estudios experimentales se intent\u00f3 ahondar sobre la importancia de los polimorfismos del gen del vdr utilizando cultivos primarios de osteoblastos humanos y cultivos tisulares de gl\u00e1ndulas paratiroides humanas de pacientes renales. Las gl\u00e1ndulas se cultivaron utilizando un sistema de cultivo cuya puesta a punto fue otro de los objetivos de la tesis. Los estudios llevados a cabo en los osteblastos en cultivo parecen indicar que el haplotipo bat en el gen del vdr ser\u00eda el que confiere una mayor sensibilidad del osteoblasto ante el est\u00edmulo con calcitriol. Por el contrario, en el caso de las gl\u00e1ndulas paratiroides ser\u00eda el haplotipo bat el que responder\u00eda mejor al calcitriol.  la combinaci\u00f3n al\u00e9lica m\u00e1s favorable en el hueso no lo es en la gl\u00e1ndula paratiroides y viceversa, lo que indicar\u00eda que la heterogeneidad al\u00e9lica, surgida de las interacciones genotipo-ambiente, se manifestar\u00eda de tal manera que un alelo se comporte de distinta forma en ambientes diferentes.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Variantes  polimorficas del gen del receptor de la vitamina d (vdr). efecto sobre la regulacion del metabolismo del hueso y de la glndula paratiroides.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Variantes  polimorficas del gen del receptor de la vitamina d (vdr). efecto sobre la regulacion del metabolismo del hueso y de la glndula paratiroides. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Daniel Serafin Alvarez Hernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/03\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Cannata Andia Jorge  Benito<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: diego Rodr\u00edguez puyol <\/li>\n<li>eliecer Coto garcia (vocal)<\/li>\n<li>adriana Dusso (vocal)<\/li>\n<li>armando Torres ramirez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Daniel Serafin Alvarez Hernandez El objetivo general de la tesis doctoral fue determinar la influencia de diferentes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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