{"id":79184,"date":"2018-03-09T23:24:58","date_gmt":"2018-03-09T23:24:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/hiperhomocisteinemia-polimorfismos-geneticos-y-sa%c2%adndrome-coronario-agudo\/"},"modified":"2018-03-09T23:24:58","modified_gmt":"2018-03-09T23:24:58","slug":"hiperhomocisteinemia-polimorfismos-geneticos-y-sa%c2%adndrome-coronario-agudo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cardiologia\/hiperhomocisteinemia-polimorfismos-geneticos-y-sa%c2%adndrome-coronario-agudo\/","title":{"rendered":"Hiperhomocisteinemia, polimorfismos gen\u00e9ticos y s\u00edndrome coronario agudo"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garc\u00eda Pinilla Jos\u00e9 Manuel <\/strong><\/h2>\n<p>Las alteraciones cong\u00e9nitas y adquiridas del metabolismo de la homociste\u00edna se han relacionado con el desarrollo de arteriosclerosis sist\u00e9mica y coronaria, sin embargo la influencia sobre el pron\u00f3stico de los pacientes con s\u00edndrome coronario agudo ha sido poco evaluado hasta el momento. Se realiz\u00f3 un estudio prospectivo en el que se incluyeron 155 pacientes ingresados en un hospital de tercer nivel en relaci\u00f3n con s\u00edndrome coronario agudo que fueron sometidos a coronariograf\u00eda en la primera semana tras el ingreso. Se determinaron las concentraciones plasm\u00e1ticas de homociste\u00edna, folatos, vitamina b12 as\u00ed como el genotipo del polimorfismo c677t de la metiltetrahidrofolato reductasa. No se encontr\u00f3 correlaci\u00f3n entre la presencia de hiperhomocisteinemia, d\u00e9ficit de folatos o la presencia del genotipo tt del polimorfismo analizado con par\u00e1metros de hipercoagulabilidad (fibrin\u00f3geno, d\u00edmeros d) o inflamaci\u00f3n (prote\u00ednas c reactiva, velocidad de sedimentaci\u00f3n globular). Se encontr\u00f3 relaci\u00f3n inversa entre la concentraci\u00f3n de homociste\u00edna y la de folatos. Los pacientes portadores del fenotipo tt presentaron mayor concentraci\u00f3n media de homociste\u00edna que los portadores de las obras dos variantes genot\u00edpicas. los portadores del genotipo tt presentaron unas caracter\u00edsticas epidemiol\u00f3gicas, cl\u00ednicas y angiogr\u00e1ficas similares a las de los otros genotipos. No se hallaron diferencias pron\u00f3sticas entre los tres genotipos. Los pacientes con concentraci\u00f3n baja de folatos presentaron un peor pron\u00f3stico con mayor tasa de eventos caridovasculares en el seguimiento a medio plazo; de hecho, la concentraci\u00f3n baja de flotas se relacion\u00f3 de manera inversa e independiente con la supervivencia total en el seguimiento. As\u00ed mismo, los pacientes con una concentraci\u00f3n elevada de homociste\u00edna presentaron mayores tasas de eventos caridovasculares en el seguimiento, identific\u00e1ndose la presencia de hiperhomocisteinemia como predictor independiente de supervivencia<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Hiperhomocisteinemia, polimorfismos gen\u00e9ticos y s\u00edndrome coronario agudo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Hiperhomocisteinemia, polimorfismos gen\u00e9ticos y s\u00edndrome coronario agudo <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garc\u00eda Pinilla Jos\u00e9 Manuel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/03\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Deteresa Galvan<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Gonz\u00e1lez santos <\/li>\n<li>Juan  Carlos Castillo dominguez (vocal)<\/li>\n<li>Luis Antonio Alonso pulpon rivera (vocal)<\/li>\n<li>Jos\u00e9 Antonio Ramirez hernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garc\u00eda Pinilla Jos\u00e9 Manuel Las alteraciones cong\u00e9nitas y adquiridas del metabolismo de la homociste\u00edna se han relacionado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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