{"id":79243,"date":"2018-03-09T23:25:02","date_gmt":"2018-03-09T23:25:02","guid":{"rendered":""},"modified":"2018-03-09T23:25:02","modified_gmt":"2018-03-09T23:25:02","slug":"estudio-de-la-farmacocinetica-de-la-metadona-tras-la-administracion-supervisada-de-la-nevirapina-didanosina-y-estavudina-en-pacientes-con-infeccion-por-el-vih-y-en-tratamiento-sustitutivo-con-metadon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-farmacocinetica-de-la-metadona-tras-la-administracion-supervisada-de-la-nevirapina-didanosina-y-estavudina-en-pacientes-con-infeccion-por-el-vih-y-en-tratamiento-sustitutivo-con-metadon\/","title":{"rendered":"Estudio de la farmacocinetica de la metadona tras la administracion supervisada de la nevirapina, didanosina y estavudina en pacientes con infeccion por el vih y en tratamiento sustitutivo con metadona"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Lucia Arroyo Domingo <\/strong><\/h2>\n<p>Se evalu\u00f3 la farmacocin\u00e9tica de la metadona (mtd)  y su principal metabolito (eddp)  en pacientes con infecci\u00f3n por el vih y a los que se les administro un r\u00e9gimen antirretroviral que inclu\u00eda nevirapina administrada en dosis \u00fanica diaria.  Se incluyeron 10 pacientes que recibieron 200 mg del f\u00e1rmaco del d\u00eda 1 al 14 del estudio,   para continuar con dosis plenas de nevirapina,  administrada en dosis \u00fanica diaria.  Se realizaron tres perfiles farmacocin\u00e9ticos, tanto para mtd como para eddp,   los d\u00edas 0,   8 y 22 del estudio durante un periodo de 12 horas.  Con los datos obtenidos,  se llevo a cabo un an\u00e1lisis farmacocin\u00e9tico no compartimental.   Los par\u00e1metros farmacocin\u00e9ticos para mtd y eddp obtenidos los d\u00edas 8 y 22 se compararon con aquellos obtenidos antes de introducir nevirapina. Despu\u00e9s de iniciar tratamiento con el f\u00e1rmaco antirretroviral,  9 de los 10 pacientes experimentaron s\u00edntomas de abstinencia a opi\u00e1ceos durante el estudio y la dosis media de metadona tuvo que ser incrementada en un 20% para controlar estos s\u00edntomas.  Tras 7 d\u00edas recibiendo 200 mg de nevirapina el auc y el cmax para mtd disminuyeron en un 63,3% y un 55,2% respectivamente.  Una reduccci\u00f3n similar se observo el d\u00eda 22 del estudio.  La modificaci\u00f3n en los par\u00e1metros farmacocin\u00e9ticos de la mtd cuando se administro de forma simultanea con nevirapina 400 mg en dosis \u00fanica son similares a los presentados por otros autores que administraron la nevirapina a dosis de 200 mg cada 12 horas.  Estos datos sugieren que la administraci\u00f3n de nvp en dosis \u00fanica,  modifica la exposici\u00f3n del organismo a la metadona de igual forma que lo hace la nevirapina administrada cada 12 horas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la farmacocinetica de la metadona tras la administracion supervisada de la nevirapina, didanosina y estavudina en pacientes con infeccion por el vih y en tratamiento sustitutivo con metadona<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la farmacocinetica de la metadona tras la administracion supervisada de la nevirapina, didanosina y estavudina en pacientes con infeccion por el vih y en tratamiento sustitutivo con metadona <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Lucia Arroyo Domingo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/03\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joaquin Portilla Sogorb<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  de los reyes Pascual perez <\/li>\n<li>Jos\u00e9 Lopez aldeguer (vocal)<\/li>\n<li>Mar\u00eda  adelina Gimeno gascon (vocal)<\/li>\n<li>Mar\u00eda  Jos\u00e9 Otero lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Lucia Arroyo Domingo Se evalu\u00f3 la farmacocin\u00e9tica de la metadona (mtd) y su principal metabolito (eddp) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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