{"id":79325,"date":"2018-03-09T23:25:10","date_gmt":"2018-03-09T23:25:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cianhidrinas-o-protegidas-racemicas-y-opticamente-activas-preparacion-y-aplicaciones-sinteticas\/"},"modified":"2018-03-09T23:25:10","modified_gmt":"2018-03-09T23:25:10","slug":"cianhidrinas-o-protegidas-racemicas-y-opticamente-activas-preparacion-y-aplicaciones-sinteticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/cianhidrinas-o-protegidas-racemicas-y-opticamente-activas-preparacion-y-aplicaciones-sinteticas\/","title":{"rendered":"Cianhidrinas o-protegidas rac\u00e9micas y \u00f3pticamente activas: preparaci\u00f3n y aplicaciones sint\u00e9ticas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alejandro Baeza Carratal\u00e1 <\/strong><\/h2>\n<p>En la presente memoria se describe la s\u00edntesis y aplicaciones de cianhidrinas o-protegidas rac\u00e9micas y enantiom\u00e9ricamente enriquecidas.En la primera parte se describen unos breves antecedentes bibliogr\u00e1ficos en torno a la s\u00edntesis rac\u00e9mica y enantioselectiva de cianhidrinas libres y o-protegidas, as\u00ed como algunas de sus aplicaciones sint\u00e9ticas y en base a los cuales se fijan los objetivos que se detallan en el apartado ii.En el tercer apartado se detalla la discusi\u00f3n de resultados que consta de:en primer lugar se describe la s\u00edntesis rac\u00e9mica de cianhidrinas o-protegidas en ausencia de disolventes catalizada por trietilamina, siendo una reacci\u00f3n muy r\u00e1pida y no necesitando la mayoria de los productos finales de purificaci\u00f3n alguna.En segundo lugar se describe la s\u00edntesis asim\u00e9trica de cianhidrinas o-benzoiladas por adici\u00f3n de cianuro de benzo\u00edlo a aldeh\u00eddos catalizada por el sistema catal\u00edtico binolam-ti(iv) a temperatura ambiente pudi\u00e9ndose recuperar el ligando binolam tras la reacci\u00f3n. Adem\u00e1s se hace un breve estudio mecan\u00edstico de la reacci\u00f3n.En tercer lugar se se describe la primera s\u00edntesis de cianhidrinas o-fosforiladas enantiom\u00e9ricamente enriquecidas por adici\u00f3n de cianofosfato de dietilo a aldeh\u00eddos catalizada por el sistema catal\u00edtico binolam-alcl a temperatura ambiente pudi\u00e9ndose recuperar el ligando binolam tras la reacci\u00f3n y obteni\u00e9ndose elevadas enantioselectividades en los productos de reacci\u00f3n. Adem\u00e1s se hace un estudio mecan\u00edstico m\u00e1s completo de la reacci\u00f3n bas\u00e1ndose en c\u00e1lculos computacionales.En cuarto lugar se describen las aplicaciones sint\u00e9ticas de los cianofosfatos quirales, profundizando en las reacciones de sustituci\u00f3n nucleof\u00edlica al\u00edlica catalizada o no por metales de transici\u00f3n sobre cianhidrinas o-protegidas enantiom\u00e9ricamente enriquecidas b,g-insaturadas.Por \u00faltimo se recoge la parte experimental, las conclusiones y los anexos (apartado iv, v y vi respectivamente).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cianhidrinas o-protegidas rac\u00e9micas y \u00f3pticamente activas: preparaci\u00f3n y aplicaciones sint\u00e9ticas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cianhidrinas o-protegidas rac\u00e9micas y \u00f3pticamente activas: preparaci\u00f3n y aplicaciones sint\u00e9ticas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alejandro Baeza Carratal\u00e1 <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alicante<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/03\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen N\u00e1jera Domingo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel \u00e1ngel Yus astiz <\/li>\n<li>Jos\u00e9 Manuel Saa rodriguez (vocal)<\/li>\n<li>pfaltz Andreas (vocal)<\/li>\n<li>Jos\u00e9 Miguel Aurrecoechea fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alejandro Baeza Carratal\u00e1 En la presente memoria se describe la s\u00edntesis y aplicaciones de cianhidrinas o-protegidas rac\u00e9micas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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