{"id":79341,"date":"2018-03-09T23:25:10","date_gmt":"2018-03-09T23:25:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/significacion-clinica-de-las-concentraciones-citosolicas-de-la-oncoproteina-cerbb2-en-el-cancer-de-mama\/"},"modified":"2018-03-09T23:25:10","modified_gmt":"2018-03-09T23:25:10","slug":"significacion-clinica-de-las-concentraciones-citosolicas-de-la-oncoproteina-cerbb2-en-el-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/significacion-clinica-de-las-concentraciones-citosolicas-de-la-oncoproteina-cerbb2-en-el-cancer-de-mama\/","title":{"rendered":"Significacion clinica de las concentraciones citosolicas de la oncoproteina cerbb2 en el cancer de mama"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rodil Diaz Juan  Antonio <\/strong><\/h2>\n<p>El prop\u00f3sito de esta tesis doctoral ha sido realizar un  an\u00e1lisis retrospectivo para determinar el pron\u00f3stico y el valor predictivo de la expresi\u00f3n citos\u00f3lica de c-erbb-2 en los tumores de mama, cuantificados mediante enzimoinmunoensayo (elisa). Tambi\u00e9n hemos determinado en 60 casos, de forma simult\u00e1nea, los valores de tinci\u00f3n inmunohistoqu\u00edmica (ihc) para la oncoprote\u00edna c-erbb-2, con el fin de comprobar si existe una relaci\u00f3n entre la determinaci\u00f3n de c-erbb-2 medida con ambas t\u00e9cnicas. Por otra parte, hemos estudiado la relaci\u00f3n de la concentraci\u00f3n citos\u00f3lica de c-erbb-2 entre el tejido tumoral mamario y el tejido adyacente no tumoral, as\u00ed como en tejido de fibroadenoma mamario y en su tejido adyacente no tumoral.  la cuantificaci\u00f3n de c-erbb-2 fue realizada en extractos de 914 casos de carcinomas primarios invasivos de mama. El tiempo libre de enfermedad (tle) y la supervivencia total (st) fueron extra\u00eddos de las 889 pacientes que no ten\u00edan met\u00e1stasis al inicio del estudio. El valor pron\u00f3stico de c-erbb-2 fue estudiado consider\u00e1ndolos como un valor continuo, dicot\u00f3mico o en variables cuartiles.  las concentraciones citos\u00f3licas c-erbb-2 mostraron una amplia variabilidad en los carcinomas mamarios (mediana 746,5 nhu\/mg; intervalo 2,8-80.000 nhu\/mg prt). Los niveles de c-erbb-2 fueron significativamente m\u00e1s elevados en los tumores moderada o pobremente diferenciados, as\u00ed como en los tumores de tipo histol\u00f3gico ductal, aneuploides o con un alto porcentaje de c\u00e9lulas en fase s.  Tambi\u00e9n la concentraci\u00f3n de c-erbb-2 fue superior en el tejido tumoral mamario con respecto al tejido adyacente no tumoral, mientras que en tejido de fibroadenoma tambi\u00e9n fue superior a su tejido adyacente mamario, siendo en cambio inferior al del tejido tumoral. Hubo una relaci\u00f3n significativa y positiva entre los valores citos\u00f3licos de c-erbb-2 y la tinci\u00f3n de inmunohistoqu\u00edmica para la oncoprote\u00edna (n=60,  p=0,04). Las conce<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Significacion clinica de las concentraciones citosolicas de la oncoproteina cerbb2 en el cancer de mama<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Significacion clinica de las concentraciones citosolicas de la oncoproteina cerbb2 en el cancer de mama <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rodil Diaz Juan  Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/03\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Fueyo Silva Antonio  Manuel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Vijande vazquez <\/li>\n<li>Manuel Garcia moran lopez (vocal)<\/li>\n<li> Sirvent calvera Juan  Jos\u00e9 (vocal)<\/li>\n<li> Garcia macias  Mar\u00eda  del carmen (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rodil Diaz Juan Antonio El prop\u00f3sito de esta tesis doctoral ha sido realizar un an\u00e1lisis retrospectivo para [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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