{"id":79342,"date":"2018-03-09T23:25:10","date_gmt":"2018-03-09T23:25:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aislamiento-y-caracterizacin-de-genes-implicados-en-la-biosintesis-del-antitumoral-estefimicina-en-streptomyces-steffisburgensis\/"},"modified":"2018-03-09T23:25:10","modified_gmt":"2018-03-09T23:25:10","slug":"aislamiento-y-caracterizacin-de-genes-implicados-en-la-biosintesis-del-antitumoral-estefimicina-en-streptomyces-steffisburgensis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-tecnologicas\/aislamiento-y-caracterizacin-de-genes-implicados-en-la-biosintesis-del-antitumoral-estefimicina-en-streptomyces-steffisburgensis\/","title":{"rendered":"Aislamiento y caracterizacin de genes implicados en la biosintesis del antitumoral estefimicina en streptomyces steffisburgensis."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sonia Gullon Blanco <\/strong><\/h2>\n<p>Estefimicina pertenece a un grupo de polic\u00e9tidos llamados antraciclinas al que pertenecen tambi\u00e9n doxorrubicina y daunorrubicina usadas en el tratamiento de diferentes tipos de c\u00e1ncer.  estefimicina no posee una actividad biol\u00f3gica destacada, sin embargo esta mol\u00e9cula posee una serie de caracter\u00edsticas estructurales que no est\u00e1n presentes en otras antraciclinas y que hacen atractivo el estudio de los genes implicados en la bios\u00edntesis de estefimicina para contribuir a la generaci\u00f3n de nuevos derivados del tipo antraciclina, con una potencial actividad antitumoral, a trav\u00e9s de la bios\u00edntesis combinatoria.  en este trabajo se describe la clonaci\u00f3n y secuenciaci\u00f3n del agrupamiento g\u00e9nico implicado en la bios\u00edntesis de estefimicina en s. Steffisburgensis. tanto la expresi\u00f3n heter\u00f3loga de algunos de los genes implicados en la bios\u00edntesis de estefimicina as\u00ed como la inactivaci\u00f3n g\u00e9nica de algunos de ellos, ha permitido identificar tres intermediarios en la ruta de bios\u00edntesis de estefimicina as\u00ed como establecer la secuencia de reacciones biosint\u00e9ticas que tienen lugar durante la bios\u00edntesis de estefimicina.  el objetivo fundamental para el futuro es la utilizaci\u00f3n de la informaci\u00f3n obtenida a partir de los genes de bios\u00edntesis de estefimicina para contribuir a la generaci\u00f3n de nuevos derivados a trav\u00e9s de bios\u00edntesis combinatoria.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aislamiento y caracterizacin de genes implicados en la biosintesis del antitumoral estefimicina en streptomyces steffisburgensis.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aislamiento y caracterizacin de genes implicados en la biosintesis del antitumoral estefimicina en streptomyces steffisburgensis. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sonia Gullon Blanco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/03\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Salas Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  evaristo Suarez fernandez <\/li>\n<li> Fernandez aparicio Jes\u00fas Manuel (vocal)<\/li>\n<li>Francisco Malpartida romero (vocal)<\/li>\n<li>ram\u00f3n Santamar\u00eda s\u00e1nchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sonia Gullon Blanco Estefimicina pertenece a un grupo de polic\u00e9tidos llamados antraciclinas al que pertenecen tambi\u00e9n doxorrubicina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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