{"id":79344,"date":"2018-03-09T23:25:10","date_gmt":"2018-03-09T23:25:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevos-analogos-estructurales-de-la-rifabutina-sintesis-y-activ-biologica-frente-a-mycobacterium-tubercolosis\/"},"modified":"2018-03-09T23:25:10","modified_gmt":"2018-03-09T23:25:10","slug":"nuevos-analogos-estructurales-de-la-rifabutina-sintesis-y-activ-biologica-frente-a-mycobacterium-tubercolosis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/nuevos-analogos-estructurales-de-la-rifabutina-sintesis-y-activ-biologica-frente-a-mycobacterium-tubercolosis\/","title":{"rendered":"Nuevos analogos estructurales de la rifabutina sintesis y activ. biologica frente a mycobacterium tubercolosis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Belen Garcia Delgado <\/strong><\/h2>\n<p>La presente memoria surge de un proyecto de colaboraci\u00f3n (universidad-ficyt-empresa) entre la compa\u00f1\u00eda qu\u00edmica  astur pharma s. A. Y el departamento de qu\u00edmica org\u00e1nica e inorg\u00e1nica de la universidad de oviedo. El objetivo del proyecto era la s\u00edntesis y el estudio de la actividad biol\u00f3gica de nuevos an\u00e1logos estructurales de la rifabutina frente al bacilo causante de la tuberculosis.  los resultados obtenidos en la memoria se describen en dos cap\u00edtulos bien diferenciados. El cap\u00edtulo 1 recoge la s\u00edntesis de nuevas 4-piperidonas, productos ampliamente estudiados en nuestro grupo de investigaci\u00f3n. Se describen dos metodolog\u00edas distintas para su preparaci\u00f3n. La primera de ellas se basa en la s\u00edntesis previa de los 2-amino-1,3-butadienos, los cuales por reacci\u00f3n de imino-diels-alder con una imina presente en el medio de reacci\u00f3n dan lugar a las meso-2,6-diaril-4-piperidonas. La segunda metodolog\u00eda permite, con el empleo de la (s)-prolina como catalizador, la formaci\u00f3n de los 2-amino-1,3-butadienos in situ que tras reaccionar con la imina conducen a los cicloaductos de manera r\u00e1pida, sencilla y en escala multigramo.  el cap\u00edtulo 2 se divide a su vez en dos partes. En la parte a,  se describe la s\u00edntesis y la determinaci\u00f3n estructural de los an\u00e1logos de la rifabutina obtenidos por reacci\u00f3n entre las 4-piperidonas sintetizadas en el cap\u00edtulo 1 y el precursor 3-amino-4-imino-rifamicina s. En la parte b, se detallan los estudios de actividad biol\u00f3gica in vitro llevados a cabo con los nuevos derivados frente a cepas de mycobacterium tuberculosis; estos ensayos ponen de manifiesto el elevado potencial antimicobacteriano de nuestros compuestos. asimismo, se recogen  los datos obtenidos mediante c\u00e1lculos te\u00f3ricos de din\u00e1mica molecular de los complejos f\u00e1rmaco-enzima que apoyan los resultados experimentales encontrados.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevos analogos estructurales de la rifabutina sintesis y activ. biologica frente a mycobacterium tubercolosis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevos analogos estructurales de la rifabutina sintesis y activ. biologica frente a mycobacterium tubercolosis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Belen Garcia Delgado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/03\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Joaquin Barluenga Mur<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: gregorio Asensio aguilar <\/li>\n<li>eduardo Rubio royo (vocal)<\/li>\n<li>Fernando Vazquez valdes (vocal)<\/li>\n<li>rosario Gonzalez garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Belen Garcia Delgado La presente memoria surge de un proyecto de colaboraci\u00f3n (universidad-ficyt-empresa) entre la compa\u00f1\u00eda [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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