{"id":79349,"date":"2018-03-09T23:25:10","date_gmt":"2018-03-09T23:25:10","guid":{"rendered":""},"modified":"2018-03-09T23:25:10","modified_gmt":"2018-03-09T23:25:10","slug":"la-modulacion-selectiva-de-los-niveles-de-glutation-con-l-2-oxo-4-tiazolidina-carboxilato-aumenta-la-eficacia-de-la-interleucina-2-e-incrementa-el-beneficio-terapeutico-de-la-bioquimioterapia-del-mela","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia-clinica\/la-modulacion-selectiva-de-los-niveles-de-glutation-con-l-2-oxo-4-tiazolidina-carboxilato-aumenta-la-eficacia-de-la-interleucina-2-e-incrementa-el-beneficio-terapeutico-de-la-bioquimioterapia-del-mela\/","title":{"rendered":"La modulaci\u00f3n selectiva de los niveles de glutati\u00f3n con l-2-oxo-4-tiazolidina carboxilato aumenta la eficacia de la interleucina-2 e incrementa el beneficio terap\u00e9utico de la bioquimioterapia del melanoma metast\u00e1tico"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Olmo Basterrechea Maite Del <\/strong><\/h2>\n<p>A pesar de las expectativas iniciales auguradas por la gran diversidad de ensayos cl\u00ednicos utilizados en el tratamiento del melanoma metast\u00e1tico, estudios recientes concluyen que la bioquimioterapia con interleucina-2 (il-2) no produce ninguna ventaja en la superficie y s\u00ed, en cambio, un aumento de los efectos secundarios severos.     la modulaci\u00f3n selectiva del contenido intracelular del glutation (gsh) en las c\u00e9lulas sanas y tumorales es una estrategia terap\u00e9utica que puede favorecer el \u00edndice terap\u00e9utico de los agentes alquilantes. en este trabajo se estudia el efecto de la il-2 u el l-2-oxo-4-tiazolidina carboxilato (otz) sobre los niveles de gsh y proliferaci\u00f3n de las c\u00e9lulas del melanoma murino b16f10, humano a375 y de las c\u00e9lulas mononucleares de sangre perif\u00e9rica (pbmcs). Asimismo, se analiza el efecto quimiosensibilizador del otz al tratamiento con ciclofosfamida (cy) y la reversi\u00f3n del efecto protumoral dela il-2. Adem\u00e1s, se ha determinado si la administraci\u00f3n previa de otz permite llevar a cabo dosis de intensificaci\u00f3n quimioterapia con el consiguiente aumento del incide terap\u00e9utico del tratamiento bioquimioter\u00e1pica con el consiguiente aumento del \u00edndice terap\u00e9utico del tratamiento bioquimioter\u00e1pico. los resultados demuestran que la il-2 aumenta los niveles intracelulares de gsh y la proliferaci\u00f3n de las c\u00e9lulas de melanoma b16f10 y a375. El otz disminuye los niveles de gsh y reduce la proliferaci\u00f3n de las c\u00e9lulas b16f20 y a375, revirtiendo, asimismo, el efecto protumoral de la il-2. Adem\u00e1s, el otz produce un efecto quimiosensibilizador de la cy sobre ambas l\u00edneas tumorales. En cambio, en las pbmcs el otz aumenta los niveles de gsh y la proliferaci\u00f3n de dichas c\u00e9lulas protegi\u00e9ndolas frente a la acci\u00f3n citot\u00f3xica de la cy. en ratones c57b16 con met\u00e1stasis hep\u00e1ticas del melanoma b16f10, la administraci\u00f3n de otz mejora el beneficio terap\u00e9utico de la il-2 y de la cy, permitiendo adem\u00e1s una intensificaci\u00f3n de dosis d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La modulaci\u00f3n selectiva de los niveles de glutati\u00f3n con l-2-oxo-4-tiazolidina carboxilato aumenta la eficacia de la interleucina-2 e incrementa el beneficio terap\u00e9utico de la bioquimioterapia del melanoma metast\u00e1tico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La modulaci\u00f3n selectiva de los niveles de glutati\u00f3n con l-2-oxo-4-tiazolidina carboxilato aumenta la eficacia de la interleucina-2 e incrementa el beneficio terap\u00e9utico de la bioquimioterapia del melanoma metast\u00e1tico <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Olmo Basterrechea Maite Del <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/03\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Teodoro Palomares Casado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: bego\u00f1a Ochoa olascoaga <\/li>\n<li>Miguel Alcaraz ba\u00f1os (vocal)<\/li>\n<li>joan Gil santano (vocal)<\/li>\n<li>Mar\u00eda  isabel Fabregat romero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Olmo Basterrechea Maite Del A pesar de las expectativas iniciales auguradas por la gran diversidad de ensayos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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