{"id":79366,"date":"2018-03-09T23:25:10","date_gmt":"2018-03-09T23:25:10","guid":{"rendered":""},"modified":"2018-03-09T23:25:10","modified_gmt":"2018-03-09T23:25:10","slug":"regulacion-de-la-expresion-del-receptor-de-insulina-y-sus-sustratos-efecto-del-tratamiento-in-vivo-con-insulina-sobre-la-senalizacion-de-la-hormona-en-higado-y-musculo-esqueletico-de-rata-con-el-enve","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/regulacion-de-la-expresion-del-receptor-de-insulina-y-sus-sustratos-efecto-del-tratamiento-in-vivo-con-insulina-sobre-la-senalizacion-de-la-hormona-en-higado-y-musculo-esqueletico-de-rata-con-el-enve\/","title":{"rendered":"Regulacion de la expresion del receptor de insulina y sus sustratos. efecto del tratamiento in vivo con insulina sobre la se\u00f1alizacion de la hormona en higado y musculo esqueletico de rata con el envejecimiento"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rosario Serrano Vargas <\/strong><\/h2>\n<p>El presente trabajo consisti\u00f3 en el estudio de la v\u00eda de se\u00f1alizaci\u00f3n de la insulina en el h\u00edgado y el m\u00fasculo esquel\u00e9tico durante el envejecimiento con el fin de dar un paso m\u00e1s en el esclarecimiento de la secuencia de acontecimientos que culminan con el desarrollo de resistencia a insulina a edades avanzadas y la aparici\u00f3n de intolerancia a glucosa. Para ello, se realiz\u00f3 un tratamiento in vivo con insulina a ratas de 3 y 24 meses de edad, lo que nos permit\u00eda analizar la capacidad de respuesta de estos tejidos a la hormona durante el envejecimiento. Despu\u00e9s de dicho tratamiento, se obtuvieron muestras de h\u00edgado y de m\u00fasculo esquel\u00e9tico para llevar a cabo un fraccionamiento subcelular de cada tejido que nos permiti\u00f3 inmunodetectar las principales prote\u00ednas de la v\u00eda de se\u00f1alizaci\u00f3n de insulina en las diferentes fracciones subcelulares obtenidas. Del mismo modo, se aisl\u00f3 el rna total de muestras procedentes de ambos tejidos para examinar por rt-pcr la expresi\u00f3n de los genes correspondientes al receptor de insulina y a sus principales sustratos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulacion de la expresion del receptor de insulina y sus sustratos. efecto del tratamiento in vivo con insulina sobre la se\u00f1alizacion de la hormona en higado y musculo esqueletico de rata con el envejecimiento<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulacion de la expresion del receptor de insulina y sus sustratos. efecto del tratamiento in vivo con insulina sobre la se\u00f1alizacion de la hormona en higado y musculo esqueletico de rata con el envejecimiento <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rosario Serrano Vargas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Castilla-la mancha<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/03\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Andres Hueva<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: josefa predestinaci\u00f3n Garc\u00eda ruiz <\/li>\n<li>Fernando Escriva pons (vocal)<\/li>\n<li>adela Rovira loscos (vocal)<\/li>\n<li> Carrascosa baeza Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosario Serrano Vargas El presente trabajo consisti\u00f3 en el estudio de la v\u00eda de se\u00f1alizaci\u00f3n de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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