{"id":79413,"date":"2006-04-04T00:00:00","date_gmt":"2006-04-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/micro-y-manoparticulas-como-adyuvantes-vacunales-frente-a-al-brucelosis-y-la-salmonelosis-ovina\/"},"modified":"2006-04-04T00:00:00","modified_gmt":"2006-04-04T00:00:00","slug":"micro-y-manoparticulas-como-adyuvantes-vacunales-frente-a-al-brucelosis-y-la-salmonelosis-ovina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacologia\/micro-y-manoparticulas-como-adyuvantes-vacunales-frente-a-al-brucelosis-y-la-salmonelosis-ovina\/","title":{"rendered":"Micro y manoparticulas como adyuvantes vacunales frente a al brucelosis y la salmonelosis ovina"},"content":{"rendered":"

Tesis doctoral de Maite Estevan Muguerza <\/strong><\/h2>\n

Brucella spp. And salmonella abortusovis cause major econ\u00ed\u00b2mic tosses in the ovine industry causing abortions, male infertility (b. Ovis and b. Melitensis) and lamb mortality (s. Abortusovis). Currently, the most universal system of prophylaxis used against ovine brucellosis, and the only practical measure to control the disease in countries with a high prevalence, consist of the vaccination of animals with live attenuated b. Melitensis strain revi. Thus, the control of s. Abortusovis infecci\u00f3n is based on the subcutaneous administration of the uve attenuated s. Abortusovis strain rv6. However, they present some drawbacks, such as the residual virulence or the interference with serological tests currently used in serodiagnosis. A new trend to minimise all of these drawbacks is based on the use of subcellular vaccines combined with controlled rel\u00e9ase vector adjuvants. In this context, we proposed the use of poly(-caprolactone) micr\u00f3particles, prepared by a new method named troms, containing an antigenic extract (hs) from b. Ovis. Due to its special physico-chemical properties we eval\u00faate the effect of several excipients on the physico-chemical and biological properties of the final product. Tne use of β-cyclodextrin in combination with pluronic f68 (f68-cd-mp) resulted the most suitable formuiation, as a consecuence, it was assesed in a protection study against experimental infeccions with b. Melitensis in balb\/c mi ce and with b. Ovis in rams. In both cases, the results showed that subcutaneous administration of f68-cd-mp micr\u00f3particles elicited a level of protection similar to that provided by the reference vaccine revl. Salmonella abortusovis is poorly studied salmonella, whose major antigenic components have not yet been characterized. Thus, in this work we studied the use of both poly(-caprolactone) micr\u00f3particles and gantrez\u00c2\u00ae an nanoparticles preparations as adjuvants for an antigenic extract of s. Abortusovis (hsao). Besides, experimental infection with s. Abortusovis strain 15\/5 was performed in mice to establish the protective efficacy of both preparations. In the experimental conditions used, a single dose of the antigenic complex hsao incorporated in nanoparticles afforded a statistical similar level of protection to that conferred by the live rev6 reference vaccine. In contrast, micr\u00f3particles containing the same antigenic complex were not protective.<\/p>\n

 <\/p>\n

Datos acad\u00e9micos de la tesis doctoral \u00abMicro y manoparticulas como adyuvantes vacunales frente a al brucelosis y la salmonelosis ovina<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Micro y manoparticulas como adyuvantes vacunales frente a al brucelosis y la salmonelosis ovina <\/li>\n
  • Autor:<\/strong>\u00a0 Maite Estevan Muguerza <\/li>\n
  • Universidad:<\/strong>\u00a0 Navarra<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 04\/04\/2006<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Carlos Gamazo De La Rasilla<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: ram\u00f3n Luis D\u00edaz Garc\u00eda <\/li>\n
        • Antonio Rebasco alvarez (vocal)<\/li>\n
        • Luis Miguel Ortega mora (vocal)<\/li>\n
        • Jos\u00e9 Luis Pedraz mu\u00f1oz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Maite Estevan Muguerza Brucella spp. And salmonella abortusovis cause major econ\u00ed\u00b2mic tosses in the ovine industry causing […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[957,17749,2714],"tags":[130579,17945,3308,39453,170454,10691],"class_list":["post-79413","post","type-post","status-publish","format-standard","hentry","category-farmacologia","category-navarra","category-vacunas","tag-antonio-rebasco-alvarez","tag-carlos-gamazo-de-la-rasilla","tag-jose-luis-pedraz-munoz","tag-luis-miguel-ortega-mora","tag-maite-estevan-muguerza","tag-ramon-luis-diaz-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79413","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=79413"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79413\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=79413"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=79413"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=79413"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}