{"id":79449,"date":"2006-06-04T00:00:00","date_gmt":"2006-06-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-neurodegeneracion-causada-por-la-interferencia-especifica-en-la-biosistesis-de-glutation\/"},"modified":"2006-06-04T00:00:00","modified_gmt":"2006-06-04T00:00:00","slug":"estudio-de-la-neurodegeneracion-causada-por-la-interferencia-especifica-en-la-biosistesis-de-glutation","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/estudio-de-la-neurodegeneracion-causada-por-la-interferencia-especifica-en-la-biosistesis-de-glutation\/","title":{"rendered":"Estudio de la neurodegeneracion causada por la interferencia especifica en la biosistesis de glutation"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Ignacio Diaz Hernandez <\/strong><\/h2>\n<p>En el presente trabajo modulamos la bios\u00edntesis de glutati\u00f3n (gsh) en cultivos primarios de neuronas, disminuyendo la concentraci\u00f3n de gsh mediante la generacion de rna de interferencia contra la enzima limitante en su bios\u00edntesis, la glutamato ciste\u00edna ligasa (gcl), e incrementando la s\u00edntesis de gsh mediante la sobreexpresi\u00f3n de dicha enzima mediante estas t\u00e9cnicas, realizamos la modulaci\u00f3n independiente de las dos subunidades de la gcl, observando disminuci\u00f3n en la actividad de la gcl y en el contenido de gsh celular al silenciar la gcl mediante rnas de interferencia contra ambas subunidades y un incremento en la actividad de la enzima y el contenido de glutati\u00f3n en el caso de sobreexpresi\u00f3n de la subunidad moduladora de la gcl.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la neurodegeneracion causada por la interferencia especifica en la biosistesis de glutation<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la neurodegeneracion causada por la interferencia especifica en la biosistesis de glutation <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Ignacio Diaz Hernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/04\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angeles Almeida Parra<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: angel Reglero <\/li>\n<li>Santiago Lamas (vocal)<\/li>\n<li>angeles Serrano Mar\u00eda (vocal)<\/li>\n<li>angeles Moro Mar\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Ignacio Diaz Hernandez En el presente trabajo modulamos la bios\u00edntesis de glutati\u00f3n (gsh) en cultivos primarios [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,9386],"tags":[170513,170512,170515,170514,170511,159024],"class_list":["post-79449","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-salamanca","tag-angel-reglero","tag-angeles-almeida-parra","tag-angeles-moro-maria","tag-angeles-serrano-maria","tag-juan-ignacio-diaz-hernandez","tag-santiago-lamas"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79449","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=79449"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79449\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=79449"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=79449"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=79449"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}