{"id":79485,"date":"2006-07-04T00:00:00","date_gmt":"2006-07-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-para-determinar-la-dosis-optima-la-tolerancia-y-la-eficacia-de-la-toxina-botulinica-en-la-fisura-anal-cronica\/"},"modified":"2006-07-04T00:00:00","modified_gmt":"2006-07-04T00:00:00","slug":"estudio-para-determinar-la-dosis-optima-la-tolerancia-y-la-eficacia-de-la-toxina-botulinica-en-la-fisura-anal-cronica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-para-determinar-la-dosis-optima-la-tolerancia-y-la-eficacia-de-la-toxina-botulinica-en-la-fisura-anal-cronica\/","title":{"rendered":"Estudio para determinar la dosis optima, la tolerancia y la eficacia de la toxina botulinica en la fisura anal cronica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Mar\u00eda Sousa Vaquero <\/strong><\/h2>\n<p>Objetivos la inyecci\u00f3n intraesfinteriana de toxina botul\u00ednica es un tratamiento alternativo de las fisuras anales cr\u00f3nicas no complicadas que se acompa\u00f1an de hiperton\u00eda esfinteriana. Nuestra hip\u00f3tesis de trabajo era probar la eficacia de dos dosis diferentes de toxina botul\u00ednica,  utilizando dosis altas, y analizar la tolerancia al tratamiento.  material y m\u00e9todo  se realiz\u00f3 un ensayo cl\u00ednico en fase ii de grupos paralelos, aleatorizado, doble ciego, de b\u00fasqueda de dosis para determinar la dosis \u00f3ptima y la efectividad y tolerancia de la neurotoxina botul\u00ednica tipo a en el tratamiento de la fisura anal cr\u00f3nica idiop\u00e1tica en una poblaci\u00f3n de pacientes de entre 18 y 70 a\u00f1os que acud\u00edan al servicio de urgencias de los hospitales universitarios virgen del roc\u00edo refiriendo dolor anal y se le diagnosticaba una fisura anal cr\u00f3nica. A todos los pacientes se les realiza una manometr\u00eda anorrectal previa y posterior a la inyecci\u00f3n. tratamiento a: 25 unidades de toxina botul\u00ednica tipo a m\u00e1s lidoca\u00edna al 2%. Tratamiento b: 50 unidades de toxina botul\u00ednica tipo a m\u00e1s lidoca\u00edna al 2%. Los pacientes eran asignados al grupo a o al grupo b de acuerdo con una tabla de permutaciones aleatorizadas. Se inyecta la dosis total en el surco interesfinteriano  a ambos lados de la fisura anal.  Los pacientes son citados a la semana de la inyecci\u00f3n  y a los 3 meses y a los 6 meses. se valoraron las siguientes variables: dolor anal defecatorio, rectorragia, estre\u00f1imiento, presi\u00f3n m\u00e1xima basal (pmb), presi\u00f3n m\u00e1xima de contracci\u00f3n voluntaria (pmcv), longitud del canal anal (lca).  resultados el estudio ha incluido a un total de 99 sujetos v\u00e1lidos; 50 pacientes en el grupo a (25 unidades) y 49 en el grupo b (50 unidades). ambos grupos son comparables en cuanto a edad, sexo, duraci\u00f3n de la sintomatolog\u00eda, presi\u00f3n m\u00e1xima basal, presi\u00f3n m\u00e1xima de contracci\u00f3n voluntaria y longitud del canal anal en la manometr\u00eda anorrectal y variab<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio para determinar la dosis optima, la tolerancia y la eficacia de la toxina botulinica en la fisura anal cronica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio para determinar la dosis optima, la tolerancia y la eficacia de la toxina botulinica en la fisura anal cronica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Mar\u00eda Sousa Vaquero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/04\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Galindo Galindo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Garcia gil <\/li>\n<li>Manuel Hidalgo pascual (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Ortega bevia (vocal)<\/li>\n<li>Jos\u00e9 Cantillana Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Mar\u00eda Sousa Vaquero Objetivos la inyecci\u00f3n intraesfinteriana de toxina botul\u00ednica es un tratamiento alternativo de las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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