{"id":79508,"date":"2006-10-04T00:00:00","date_gmt":"2006-10-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modificaciones-de-la-cromatina-en-la-regulacion-de-la-expresion-genica-durante-la-pancreatitis-aguda\/"},"modified":"2006-10-04T00:00:00","modified_gmt":"2006-10-04T00:00:00","slug":"modificaciones-de-la-cromatina-en-la-regulacion-de-la-expresion-genica-durante-la-pancreatitis-aguda","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/modificaciones-de-la-cromatina-en-la-regulacion-de-la-expresion-genica-durante-la-pancreatitis-aguda\/","title":{"rendered":"\u00abmodificaciones de la cromatina en la regulaci\u00f3n de la expresi\u00f3n g\u00e9nica durante la pancreatitis aguda\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Sandoval Del Amor Juan <\/strong><\/h2>\n<p>La pancreatitis aguda necrotica (pa) presenta una tasa de mortalidad relativamente alta debido a un fallo  multiorg\u00e1nico en las  etapas finales de la patolog\u00eda. Mucho trabajo se ha invertido en esta \u00e1rea de investigaci\u00f3n.  sin embargo, los mecanismos moleculares que inician la enfermedad no estan esclarecidos hasta el momento.  en este trabajo de tesis doctoral se ha estudiado la regulaci\u00f3n de la expresi\u00f3n g\u00e9nica de diferentes genes  que estan implicados  en el inicio y desarro110 de la pancreatitis aguda. Se ha enfocado la investigaci\u00f3n en la  caracterizaci\u00f3n de las modificaciones de  histonas, transducci\u00f3n de se\u00f1al y el remodelamiento de la cromatina en los promotores de los genes: \u00abearly growth response 1\u00bb (  egr-1), \u00abinter-cellular adhesion  molecule 1\u00bb (icam-1),  \u00abinterleukin 6\u00bb (il-6) and \u00abtumor necrosis factor a.\u00bb (Tnfa.). Para un an\u00e1lisis  exhaustivo y completo, se han utilizado un modelo in viva de pa en rata mediante la administraci6n de taurocolata sodico y un  modelo in vitro en cultivo de c\u00e9lulas acinares ar42j.  durante el desarrollo de este trabajo hemos desarrollado una nueva aplicaci6n de la metodolog\u00eda de inmunoprecipitaci\u00f3n de cromatina (chip), que hemos liamado rnapoi-chip. Esta aplicaci6n permite el an\u00e1lisis de la transcripci\u00f3n genica en tiempo real y consiste en la detecci\u00f3n de la rna polimerasa ii en la regi\u00f3n codificante de los genes.  adem\u00e1s, hemos estudiado la acci\u00f3n de la pentoxifilina, un posible agente terapeutico frente a la pa, en la expresi\u00f3n de los genes seleccionados. nuestros resultados apoyan el uso de la pentoxifilina como un agente terapeutico en las fases iniciales de la patolog\u00eda, ya que activa como un regulador de la expresi\u00f3n de los genes implicados en el desarrollo de la pa.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abmodificaciones de la cromatina en la regulaci\u00f3n de la expresi\u00f3n g\u00e9nica durante la pancreatitis aguda\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abmodificaciones de la cromatina en la regulaci\u00f3n de la expresi\u00f3n g\u00e9nica durante la pancreatitis aguda\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Sandoval Del Amor Juan <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/04\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Gerardo Lopez Rodas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Franco vera <\/li>\n<li>Luis Sabater ort\u00ed (vocal)<\/li>\n<li>manel Esteller (vocal)<\/li>\n<li>ferran Azorin marin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sandoval Del Amor Juan La pancreatitis aguda necrotica (pa) presenta una tasa de mortalidad relativamente alta debido 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