{"id":79565,"date":"2018-03-09T23:25:26","date_gmt":"2018-03-09T23:25:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-a-fosfoprotea%c2%adna-tipo-fosducina-phlp-en-astrocitos-papel-en-la-regulacion-del-receptor-opioide-delta\/"},"modified":"2018-03-09T23:25:26","modified_gmt":"2018-03-09T23:25:26","slug":"estudio-del-a-fosfoprotea%c2%adna-tipo-fosducina-phlp-en-astrocitos-papel-en-la-regulacion-del-receptor-opioide-delta","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-a-fosfoprotea%c2%adna-tipo-fosducina-phlp-en-astrocitos-papel-en-la-regulacion-del-receptor-opioide-delta\/","title":{"rendered":"Estudio del a fosfoprote\u00edna tipo fosducina (phlp) en astrocitos: papel en la regulaci\u00f3n del receptor opioide delta"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Montero Otero <\/strong><\/h2>\n<p>Los receptores opioides, al igual que el resto de los miembros de la familia de receptores acoplados a prote\u00ednas g, presentan complejos mecanismos de regulaci\u00f3n que modulan la eficacia de la transducci\u00f3n de la se\u00f1al y protegen a la c\u00e9lula frente a una estimulaci\u00f3n excesiva o prolongada.     la presente tesis doctoral proporciona datos sobre el papel esencial de las propiedades de la familia de la fosducina, en concreto la isoforma larga de la prote\u00edna tipo fosducina (phlpl) en la regulaci\u00f3n de las prote\u00ednas g y la funcionalidad del receptor opioide delta en el astrocito. El estudio realizado indica que la c\u00e9lula astroglial constituye un modelo muy adecuado donde realizar estudios funcionales y moleculares, donde se demuestra mediante t\u00e9cnicas de \u00abwestern blot\u00bb y microscop\u00eda confocal la existencia de toda la maquinaria de se\u00f1alizaci\u00f3n vinculada a receptores acoplados a prote\u00ednas g: variantes glicosiladas de receptores opioides, capaces de co-localizar en la membrana celular del astrocito siendo mayoritario el tipo delta: subunidades galfa y d\u00edmeros gbetagama, as\u00ed como modulares de la funci\u00f3n de las prote\u00ednas g, que coinciden con las descritas en snc. Se describen en el astrocito prote\u00ednas rgs de las familias r4 (rgs 4), r7 (rgs 7,9 y 11) y rz (rgs 17 y 20) que act\u00faan sobre la subunidad galfa, y prote\u00ednas de la familia de la fosducina, phlpl, cuya funci\u00f3n es unirse a los d\u00edmeros gbetagamma interfiriendo su acci\u00f3n sobre efectores y evitando su asociaci\u00f3n a quinasa que pudieran acceder al entorno del receptor y fosforilar su estructura. Este estudio aporta la primera evidencia de la presente de phlpl en astrocitos dividida en una fracci\u00f3n glicosilada de 55kda y otra no glicosilada de 38 kda. Ambas fracciones se encuentran en estado basal distribuida por el n\u00facleo, citosol y membrana plasm\u00e1tica de la c\u00e9lula astroglial.  la estimulaci\u00f3n del receptor opioide provoca la redistribuci\u00f3n de phlpl y altera el grado de asociaci\u00f3n de phlpl con<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del a fosfoprote\u00edna tipo fosducina (phlp) en astrocitos: papel en la regulaci\u00f3n del receptor opioide delta<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del a fosfoprote\u00edna tipo fosducina (phlp) en astrocitos: papel en la regulaci\u00f3n del receptor opioide delta <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Montero Otero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/04\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Javier Garz\u00f3n  Ni\u00f1o<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: \u00e1ngel Villar del fresno <\/li>\n<li>olga Valverde granados (vocal)<\/li>\n<li>nazario Rubio arazuri (vocal)<\/li>\n<li>Juan  Fernando Herrero  gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Montero Otero Los receptores opioides, al igual que el resto de los miembros de la familia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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