{"id":79580,"date":"2018-03-09T23:25:26","date_gmt":"2018-03-09T23:25:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/imiculacion-del-receptor-de-dioxina-en-desarrollo-tumoral-identificacion-de-rutas-de-senalizacion-y-mecanismos-epigeneticos\/"},"modified":"2018-03-09T23:25:26","modified_gmt":"2018-03-09T23:25:26","slug":"imiculacion-del-receptor-de-dioxina-en-desarrollo-tumoral-identificacion-de-rutas-de-senalizacion-y-mecanismos-epigeneticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/extremadura\/imiculacion-del-receptor-de-dioxina-en-desarrollo-tumoral-identificacion-de-rutas-de-senalizacion-y-mecanismos-epigeneticos\/","title":{"rendered":"Imiculaci\u00f3n del receptor de dioxina en desarrollo tumoral. identificaci\u00f3n de rutas de se\u00f1alizaci\u00f3n y mecanismos epigen\u00e9ticos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mulero Navarro Sonia Mar\u00eda <\/strong><\/h2>\n<p>Aunque el receptor de dioxina (ahr) es considerado un importante regulador de procesos de destoxificaci\u00f3n, su papel en desarrollo tumoral en ausencia de xenobi\u00f3ticos permanece todav\u00eda desconocido. Con el objeto de analizar si el ahr es relevante en c\u00e1ncer, y si su activaci\u00f3n condiciona la capacidad tumoral de la c\u00e9lula, en la primera parte del trabajo, hemos producido l\u00edneas inmortalizadas de fibrolbastos de gl\u00e1ndula mamaria de rat\u00f3n silvestre (t-fgm-ahr +\/+) y mutante (t-fgm-ahr -\/-) para el ahr mediante contrasfecci\u00f3n estable con el ant\u00edgeno _t largo del retrovirus  sv-40 y el proto-oncogen c-h-ras. Ambas l\u00edneas celulares tienen un fenotipo fibrobl\u00e1stico, proliferaci\u00f3n, tiempo de duplicaci\u00f3n, expresi\u00f3n y actividad de sv-40 y c-h-ras y distribuci\u00f3n en ciclo celular, similares. Los miofibroblastos ahr +\/+ y ahr -\/- son capaces de proliferar independientes en matriz semis\u00f3lida. Sin embargo, los t-fgm-ahr -\/- tienen una capacidad reducida (en torno a 4 veces menos) para inducir tumores subcut\u00e1neos (leiomiosarcomas) en ratones nod-scid y nula en ratones at\u00edmicos un\/un comparado con los miobifroblastos t-fgm-ahr +\/+. En cultivo, los t-fgm-ahr -\/- tienen disminuidas la capacidad de migraci\u00f3n en matriz de col\u00e1geno i y la capacidad de formaci\u00f3n de lamelipodios. El receptor de tipo  del factor de crecimiento de endotelio vascular (vegfr-1), que regula la migraci\u00f3n celular y la formaci\u00f3n de vasos sangu\u00edneos, tiene una expresi\u00f3n marcadamente disminuida en t-fgm-ahr -\/-. A trav\u00e9s de la ruta de se\u00f1alizaci\u00f3n de erk-fak-pkb\/akt-rac-1, la cual contribuye a la regulaci\u00f3n de la movilidad e invasi\u00f3n celular, observamos un descenso en el nivel de fosforilaci\u00f3n de fak y en los nivelas activos de akt, erk y rac-1. Sin embargo, las c\u00e9lulas t-fgm-ahr -\/- tienen una actividad c-src (tirosina quinasa que regula al fosforilaci\u00f3n de fak) aumentada, lo que sugiere que la menor activaci\u00f3n de fak est\u00e1 regulada por mecanismos alternativos. Entre estos mecanism<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Imiculaci\u00f3n del receptor de dioxina en desarrollo tumoral. identificaci\u00f3n de rutas de se\u00f1alizaci\u00f3n y mecanismos epigen\u00e9ticos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Imiculaci\u00f3n del receptor de dioxina en desarrollo tumoral. identificaci\u00f3n de rutas de se\u00f1alizaci\u00f3n y mecanismos epigen\u00e9ticos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mulero Navarro Sonia Mar\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/04\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Fern\u00e1ndez Salguero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Lopez otin <\/li>\n<li>isidro Javier S\u00e1nchez Garc\u00eda (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Rojas caba\u00f1eros (vocal)<\/li>\n<li>Francisco Centeno velazaquez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mulero Navarro Sonia Mar\u00eda Aunque el receptor de dioxina (ahr) es considerado un importante regulador de procesos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9399,949,9076,1593],"tags":[5834,170751,40871,42262,170750,41978],"class_list":["post-79580","post","type-post","status-publish","format-standard","hentry","category-cultivo-celular","category-extremadura","category-necesidades-alimentarias","category-vino","tag-carlos-lopez-otin","tag-francisco-centeno-velazaquez","tag-isidro-javier-sanchez-garcia","tag-jose-maria-rojas-cabaneros","tag-mulero-navarro-sonia-maria","tag-pedro-fernandez-salguero"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79580","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=79580"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79580\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=79580"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=79580"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=79580"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}