{"id":79595,"date":"2018-03-09T23:25:26","date_gmt":"2018-03-09T23:25:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/relevancia-funcional-y-arquitectura-molecular-de-los-dominios-citoplasmaticos-del-canal-de-potasio-herg\/"},"modified":"2018-03-09T23:25:26","modified_gmt":"2018-03-09T23:25:26","slug":"relevancia-funcional-y-arquitectura-molecular-de-los-dominios-citoplasmaticos-del-canal-de-potasio-herg","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/relevancia-funcional-y-arquitectura-molecular-de-los-dominios-citoplasmaticos-del-canal-de-potasio-herg\/","title":{"rendered":"Relevancia funcional y arquitectura molecular de los dominios citoplasmaticos del canal de potasio herg"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Diego Garcia Manso <\/strong><\/h2>\n<p>Este trabajo de tesis ha supuesto la constataci\u00f3n de que las particulares caracter\u00edsticas cin\u00e9ticas de apertura y cierre del canal herg, que son esenciales para sus importantes papeles fisiopatol\u00f3gicos, se deben a la presencia combinada en su extremo amino terminal de dos dominios funcionalmente distintos: el dominio eag y el dominio proximal.  el trabajo demuestra por un lado, la existencia de interacciones entre el dominio eag del extremo amino y el lazo intracelular s4-s5 del cuerpo central del canal, y que sirve como elemento de conexi\u00f3n entre el sensor de voltaje y la maquinaria de apertura del poro i\u00f3nico del canal, interacciones que son determinantes para las particulares caracter\u00edsticas cin\u00e9ticas funcionales de herg.  puesto que para el entendimiento de estas interacciones es esencial conocer las distancias entre algunos de los dominios intracelulares del canal, as\u00ed como otros aspectos de su organizaci\u00f3n estructural, que son inabordables mediante los estudios cl\u00e1sicos de relaciones estructura-funci\u00f3n, tambi\u00e9n se ha estudiado mediante un novedoso abordaje experimental la arquitectura molecular de los dominios intracelulares de herg que posibilita la existencia de las citadas interacciones. Para ello, se han analizado mediante la t\u00e9cnica de fret (fluorescence resonance energy transfer) las distancias moleculares entre diferentes dominios intracelulares de la prote\u00edna del canal in vivo, utilizando para ello la expresi\u00f3n funcional de colecciones de canales herg fluorescentes en los que los fluor\u00f3foros yfp y cfp fueron insertados a todo lo largo de la secuencia polipept\u00eddica de herg utilizando el comportamiento al azar de transposones recombinantes e hiperactivos mediante reacciones de transposici\u00f3n in vitro.  la arquitectura molecular de herg responde a un esquema en el cual los extremos amino terminales del canal tetram\u00e9rico funcional se encuentran empaquetados, pr\u00f3ximos al lazo s4-s5 y en una posici\u00f3n cercan<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Relevancia funcional y arquitectura molecular de los dominios citoplasmaticos del canal de potasio herg<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Relevancia funcional y arquitectura molecular de los dominios citoplasmaticos del canal de potasio herg <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Diego Garcia Manso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/04\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> De La Pe\u00f1a Cortines Mar\u00eda  Del Pilar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Sanchez lazo pedro manuel <\/li>\n<li>f\u00e9lix Viana de la iglesia (vocal)<\/li>\n<li>Juan  Jos\u00e9 Toledo  aral (vocal)<\/li>\n<li>teresa Giraldez fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Diego Garcia Manso Este trabajo de tesis ha supuesto la constataci\u00f3n de que las particulares caracter\u00edsticas cin\u00e9ticas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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