{"id":7969,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/efectos-secundarios-del-valproato-a-altas-dosis-en-el-sindrome-de-west\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"efectos-secundarios-del-valproato-a-altas-dosis-en-el-sindrome-de-west","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-secundarios-del-valproato-a-altas-dosis-en-el-sindrome-de-west\/","title":{"rendered":"Efectos secundarios del valproato a altas dosis en el sindrome de west"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Garaizar Axpe <\/strong><\/h2>\n<p>Hemos estudiado los efectos secundarios de la medicacion en 25 casos con s. West tratados con valproato sodico en monoterapia como primera opcion terapeutica, a 200 mg\/kg\/dia hasta la resolucion de la hipsarritmia (17 +_ 7 dias), y a dosis estandar (36 +_ 19 mg\/kg\/dia) posteriormente, realizando un seguimiento longitudinal de caracter clinico, analitico y, en un peque\u00f1o numero de casos, tambien epidemiologico.  observamos durante la primera semana de tratamiento, vomitos, sedacion (76%) e hiperamonemia (10%); eventos que ceden o desaparecen durante la segunda semana, cuando aparecen diarrea (50%) y plaquetopenia (48%). Otros efectos secundarios detectados son: tendencia a la anemia macrocitica, eritema perioral, descenso franco de carnitina plasmatica, disminucion inicial transitoria de linfocitos t (subpoblacion cd4), secuestro del calcio serico y elevacion leve del acido urico plasmatico. No hemos detectado disfuncion hepatica o renal. Las infecciones intercurrentes influyen sobre el metabolismo del farmaco y sus efectos secundarios. A su vez, esta pauta de tratamiento aumenta ligeramente la susceptibilidad a las infecciones. Los niveles sericos del farmaco disminuyen espontaneamente y muestran una estrecha relacion con la evolucion de la cifra de plaquetas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos secundarios del valproato a altas dosis en el sindrome de west<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos secundarios del valproato a altas dosis en el sindrome de west <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Garaizar Axpe <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Rodriguez Soriano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Jose Zarranz Imirizaldu <\/li>\n<li>Jos\u00e9 Luis Herranz Fernandez (vocal)<\/li>\n<li>Juan  Antonio Armijo Simon (vocal)<\/li>\n<li>Rafael Palencia Luaces (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Garaizar Axpe Hemos estudiado los efectos secundarios de la medicacion en 25 casos con s. West [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[44,155,9,189,12909,161],"tags":[28216,28217,10699,13452,26318,12810],"class_list":["post-7969","post","type-post","status-publish","format-standard","hentry","category-accion-de-los-farmacos","category-ciencias-clinicas","category-ciencias-medicas","category-farmacodinamia","category-pais-vasco-euskal-herriko-unibertsitatea","category-pediatria","tag-carmen-garaizar-axpe","tag-jose-luis-herranz-fernandez","tag-juan-antonio-armijo-simon","tag-juan-jose-zarranz-imirizaldu","tag-juan-rodriguez-soriano","tag-rafael-palencia-luaces"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/7969","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=7969"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/7969\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=7969"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=7969"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=7969"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}