{"id":79725,"date":"2018-03-09T23:25:33","date_gmt":"2018-03-09T23:25:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-del-factor-de-transcripcion-snail1-sobre-la-expresion-del-gen-vdr-y-las-acciones-de-la-1a25-dihidroxivitamina-d3-en-cancer-de-colon\/"},"modified":"2018-03-09T23:25:33","modified_gmt":"2018-03-09T23:25:33","slug":"efecto-del-factor-de-transcripcion-snail1-sobre-la-expresion-del-gen-vdr-y-las-acciones-de-la-1a25-dihidroxivitamina-d3-en-cancer-de-colon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-del-factor-de-transcripcion-snail1-sobre-la-expresion-del-gen-vdr-y-las-acciones-de-la-1a25-dihidroxivitamina-d3-en-cancer-de-colon\/","title":{"rendered":"Efecto del factor de transcripci\u00f3n snail1 sobre la expresi\u00f3n del gen vdr y las acciones de la 1a,25-dihidroxivitamina d3 en c\u00e1ncer de colon"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Larriba Mu\u00f1oz Mar\u00eda Jes\u00fas <\/strong><\/h2>\n<p>El c\u00e1ncer colorrectal (crc) es una de las neoplasias de mayor incidencia y mortalidad. Estudios epidemiol\u00f3gicos y pre-cl\u00ednicos indican que la 1a, 25-dihidroxivitamina d3 (1a,25(oh)2d3), el metabolito m\u00e1s activo de la vitamina d3, tiene actividad anti-tumoral frente al crc. Resultados previos de nuestro laboratorio muestran que la 1a,25(oh)2d3 y algunos de sus an\u00e1logos inhiben la proliferaci\u00f3n y promueven la diferenciaci\u00f3n epitelial de las c\u00e9lulas sw480-adh de c\u00e1ncer de colon humano. Estas acciones se basan, principalmente, en la inducci\u00f3n transcripcional del gen cdh1\/e-cadherina y en el bloqueo de la ruta wnt\/b-catenina, frecuentemente alterada en crc. La mayor\u00eda, si no todas, las acciones de la 1a,25(oh)2d3 est\u00e1n mediadas por el receptor de vitamina d (vdr), un factor de transcripci\u00f3n de la superfamilia de los receptores nucleares cuya expresi\u00f3n se pierde durante la progresi\u00f3n del crc. Por el contrario, la expresi\u00f3n del factor de transcripci\u00f3n snail1, represor de cdh1 e inductor de la transici\u00f3n epitelio-mes\u00e9nquima, aumenta durante la progresi\u00f3n de algunos carcinomas y se ha asociado a la adquisici\u00f3n de propiedades migratorias e invasivas.  los resultados presentados en esta memoria muestran que tanto la expresi\u00f3n ect\u00f3pica de snail1 como la elevaci\u00f3n de sus niveles end\u00f3genos en c\u00e9lulas de c\u00e1ncer de colon humano provocan la disminuci\u00f3n de la cantidad de rna y prote\u00edna de vdr. El estudio en detalle nos ha permitido comprobar que snail1 reprime la expresi\u00f3n de vdr a dos niveles: (a) transcripcionalmente, uni\u00e9ndose a tres cajas e de su promotor; y (b) post-transcripcionalmente, disminuyendo la estabilidad del rna. Esta represi\u00f3n bloquea la regulaci\u00f3n de los genes diana de 1a,25(oh)2d3 y el efecto antag\u00f3nico que \u00e9sta ejerce sobre la ruta wnt\/b-catenina. Asimismo, snail1 inhibe las acciones pro-diferenciadoras, anti-migratorias y anti-proliferativas de la 1a,25(oh)2d3 en c\u00e9lulas de c\u00e1ncer de colon en cult<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto del factor de transcripci\u00f3n snail1 sobre la expresi\u00f3n del gen vdr y las acciones de la 1a,25-dihidroxivitamina d3 en c\u00e1ncer de colon<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto del factor de transcripci\u00f3n snail1 sobre la expresi\u00f3n del gen vdr y las acciones de la 1a,25-dihidroxivitamina d3 en c\u00e1ncer de colon <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Larriba Mu\u00f1oz Mar\u00eda Jes\u00fas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/04\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alberto Mu\u00f1oz Terol<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eugenio Miguel angel Santos de dios <\/li>\n<li>amparo Cano garcia (vocal)<\/li>\n<li>Javier Le\u00f3n serrano (vocal)<\/li>\n<li>Antonio Garcia de herreros madue\u00f1o (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Larriba Mu\u00f1oz Mar\u00eda Jes\u00fas El c\u00e1ncer colorrectal (crc) es una de las neoplasias de mayor incidencia y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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