{"id":79748,"date":"2006-02-05T00:00:00","date_gmt":"2006-02-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-los-antagonistas-del-receptor-de-muerte-cd95-apo-1-fas-faiml-y-lifeguard-en-el-sistema-nervioso\/"},"modified":"2006-02-05T00:00:00","modified_gmt":"2006-02-05T00:00:00","slug":"caracterizacion-de-los-antagonistas-del-receptor-de-muerte-cd95-apo-1-fas-faiml-y-lifeguard-en-el-sistema-nervioso","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-de-los-antagonistas-del-receptor-de-muerte-cd95-apo-1-fas-faiml-y-lifeguard-en-el-sistema-nervioso\/","title":{"rendered":"Caracterizaci\u00f3n de los antagonistas del receptor de muerte cd95\/apo-1\/fas -faiml y lifeguard- en el sistema nervioso"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miguel Francisco Segura Ginard <\/strong><\/h2>\n<p>La apoptosis es un mecanismo fisiol\u00f3gico que contribuye a regular el n\u00famero de c\u00e9lulas de un organismo de tal forma que aqu\u00e9llas que realizan funciones transitorias, que est\u00e1n lesionadas, o en exceso, ser\u00e1n eliminadas. \u00e9ste es un proceso estrictamente regulado durante el desarrollo embrionario e \u00edntimamente ligado con el inicio o progresi\u00f3n de determinadas patolog\u00edas. As\u00ed pues, el exceso de apoptosis contribuye al desarrollo de enfermedades neurodegenerativas mientras que su defecto ser\u00eda el origen de neoplasias. El principal regulador del proceso apopt\u00f3tico es la activaci\u00f3n de las caspasas, ciste\u00edna-proteasas con especificidad para residuos de aspartato. Los principales mecanismos que activan las caspasas son la salida de citocromo c de la mitocondria por una alteraci\u00f3n de la funci\u00f3n mitocondrial, y la activaci\u00f3n de prote\u00ednas de membrana denominadas receptores de muerte (drs, death receptors). Estos \u00faltimos han sido ampliamente caracterizados en el sistema inmune, mientras que en tejidos como el sistema nervioso sus funciones est\u00e1n en las fases iniciales de caracterizaci\u00f3n. el objetivo del presente trabajo es contribuir a esclarecer los mecanismos moleculares que regulan la actividad de estos receptores en el sistema nervioso, a trav\u00e9s de la caracterizaci\u00f3n funcional de dos nuevas prote\u00ednas, faim y lifeguard, propuestas inicialmente como antagonistas del receptor de muerte cd95\/fas\/apo-1. Para ello se han usado las l\u00edneas celulares pc12 y sh-sy5y, ampliamente utilizadas en modelos de diferenciaci\u00f3n y de muerte cd95\/fas\/apo-1. Para ello se han usado las l\u00edneas celulares pc12 y sh-sy5y, ampliamente utilizadas en modelos de diferenciaci\u00f3n y muerte celular, junto con cultivos primarios de neuronas corticales y neuronas granulares de cerebelo. en la primera parte de este trabajo se describe la clonaci\u00f3n del ort\u00f3logo de rat\u00f3n de lifeguard, y su caracterizaci\u00f3n como antagonista funcional de cd95 en el sistema nervioso. Hemos demostrado q<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de los antagonistas del receptor de muerte cd95\/apo-1\/fas -faiml y lifeguard- en el sistema nervioso<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de los antagonistas del receptor de muerte cd95\/apo-1\/fas -faiml y lifeguard- en el sistema nervioso <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miguel Francisco Segura Ginard <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Lleida<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/05\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joan Xavier Comella Carnice<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: faustino Mollinedo Garc\u00eda <\/li>\n<li>ram\u00f3n Trullas oliva (vocal)<\/li>\n<li>Ana Martin-villalba (vocal)<\/li>\n<li>Jos\u00e9 Rodriguez alvarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miguel Francisco Segura Ginard La apoptosis es un mecanismo fisiol\u00f3gico que contribuye a regular el n\u00famero de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,9,18842],"tags":[171080,5661,41179,67331,171079,14027],"class_list":["post-79748","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-ciencias-medicas","category-lleida","tag-ana-martin-villalba","tag-faustino-mollinedo-garcia","tag-joan-xavier-comella-carnice","tag-jose-rodriguez-alvarez","tag-miguel-francisco-segura-ginard","tag-ramon-trullas-oliva"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79748","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=79748"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79748\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=79748"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=79748"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=79748"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}