{"id":79785,"date":"2006-05-05T00:00:00","date_gmt":"2006-05-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-sistema-inmune-en-la-proliferacion-acumulacion-de-celulas-plasmaticas-en-gammapatias-monoclonales\/"},"modified":"2006-05-05T00:00:00","modified_gmt":"2006-05-05T00:00:00","slug":"papel-del-sistema-inmune-en-la-proliferacion-acumulacion-de-celulas-plasmaticas-en-gammapatias-monoclonales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/hematologia\/papel-del-sistema-inmune-en-la-proliferacion-acumulacion-de-celulas-plasmaticas-en-gammapatias-monoclonales\/","title":{"rendered":"Papel del sistema inmune en la proliferacion\/acumulacion de celulas plasmaticas en gammapatias monoclonales"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Perez De Andr\u00e9s Martin <\/strong><\/h2>\n<p>Objetivo: partiendo de la hip\u00f3tesis de que el micromedioambiente inmune de la m\u00e9dula \u00f3sea (mo) podr\u00eda tener un papel importante en el control del crecimiento, supervivencia y resistencia a drogas de las c\u00e9lulas plasm\u00e1ticas (cp), esto podr\u00eda traducirse en diferentes patrones de expresi\u00f3n de mol\u00e9culas implicadas en la respuesta inmune y alteraciones en la distribuci\u00f3n y  las caracter\u00edsticas funcionales de los linfocitos t en la mo entre pacientes con formas benignas de gammapat\u00eda monoclonal (gm), como la gm de significado incierto (gmsi), y gm agresivas, como el mieloma m\u00faltiple (mm) y la leucemia de c\u00e9lulas plasm\u00e1ticas (lcp). Tambi\u00e9n evaluamos el comportamiento cl\u00ednico y evolutivo de pacientes con mm de acuerdo a las interacciones de las cp clonales con el micromedioambiente de la mo.  muestras: se emplearon 61 muestras de mo de pacientes con  gm al diagn\u00f3stico -30 gmsi, 27 mm, y 4 lcp- as\u00ed como mo de 10 individuos sanos. El impacto cl\u00ednico se estudio en 43 pacientes con mm. resultados y conclusiones: las cp clonales presentaban niveles significativamente incrementados de cd56, cd86, y cd126 as\u00ed como cantidades disminuidas de cd38 en todas las gm. Junto con esto, hla-i y  2-microglobulina estaban anormalmente sobre-expresados en gmsi y la expresi\u00f3n de cd40 estaba disminuida en mm y lcp. As\u00ed mismo, se encontr\u00f3 un aumento progresivo de los niveles solubles de  2-microglobulina de la gmsi a pacientes con mm y lcp. Por el contrario, todos los grupos mostraban cantidades solubles y en superficie similares de cd126, cd130 y cd95, excepto un incremento de los niveles solubles de cd95 observados en lcp. Tambi\u00e9n encontramos un incremento significativo de la infiltraci\u00f3n por c\u00e9lulas t en mo en todos los grupos de pacientes, a expensas de linfocitos t cd4+cd8- y cd4-cd8- y de las subpoblaciones t citot\u00f3xicas\/efectoras tanto  cd4+cd28- como cd8+cd28-, asociado con expansiones tcr-v  en c\u00e9lulas t cd4+ y cd8+ de la mayoria de gmsi, mm, y lcp. Mas a\u00fa<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del sistema inmune en la proliferacion\/acumulacion de celulas plasmaticas en gammapatias monoclonales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del sistema inmune en la proliferacion\/acumulacion de celulas plasmaticas en gammapatias monoclonales <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Perez De Andr\u00e9s Martin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/05\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Orfeo De Matos Alberto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rogelio Gonzalez sarmiento <\/li>\n<li>josep Nomdedeu guinot (vocal)<\/li>\n<li>joaqu\u00edn D\u00edaz mediavilla (vocal)<\/li>\n<li>Jos\u00e9 Lahuerta Juan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Perez De Andr\u00e9s Martin Objetivo: partiendo de la hip\u00f3tesis de que el micromedioambiente inmune de la m\u00e9dula [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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