{"id":79790,"date":"2006-05-05T00:00:00","date_gmt":"2006-05-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-farmacologica-de-la-expresion-genica-y-proteica-en-organos-diana-durante-la-hipertension-arterial\/"},"modified":"2006-05-05T00:00:00","modified_gmt":"2006-05-05T00:00:00","slug":"modulacion-farmacologica-de-la-expresion-genica-y-proteica-en-organos-diana-durante-la-hipertension-arterial","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/patologia-experimental\/modulacion-farmacologica-de-la-expresion-genica-y-proteica-en-organos-diana-durante-la-hipertension-arterial\/","title":{"rendered":"Modulaci\u00f3n farmacol\u00f3gica de la expresi\u00f3n g\u00e9nica y prot\u00e9ica en \u00f3rganos diana durante la hipertensi\u00f3n arterial"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alberto Lazaro Fern\u00e1ndez <\/strong><\/h2>\n<p>La hipertensi\u00f3n arterial es la enfermedad cr\u00f3nica mas frecuente en el mundo desarrollado, y est\u00e1 considerada como la principal causa de morbi-mortalidad cardiovascular a nivel mundial. Entre otros efectos, lidera la progresi\u00f3n hacia la enfermedad cr\u00f3nica renal, y es la mayor causa de desarrollo de hipertrofia ventricular izquierda (hvi), el mayor predictor de fallo cardiaco mediado por hipertensi\u00f3n en un modelo experimental animal, con el fin de elucidar los mecanismos moleculares subyacentes al da\u00f1o org\u00e1nico. Adicionalmente hemos analizado el efecto del control de la presi\u00f3n arterial en la regresi\u00f3n del da\u00f1o, en base a dos terapias antihipertensivas com\u00fanmente utilizadas: un inhibidor de la enzima convertidora de angiotensina (ieca) y un antagonista delos receptores at1 de la angiotensina ii (ara ii). Mediante una aproximaci\u00f3n cl\u00e1sica hemos constatado que el da\u00f1o renal est\u00e1 asociado a un aumento del estr\u00e9s oxidativo (debido en parte a una disminuci\u00f3n de las enximas antioxidantes) y activaci\u00f3n de v\u00edas apopt\u00f3ticas y proinflamatorias. Por otra parte, mediante una doble aproximaci\u00f3n gen\u00f3mica y prote\u00f3mica hemos demostrado que tanto el perfil g\u00e9nico como el proteico de los corazones con hvi difieren sustancialmente del de los corazones normales. El tratamiento con ieca y ara ii disminuy\u00f3 significativamente todos los par\u00e1metros de da\u00f1o renal y da\u00f1o cardiaco, incluso regresando la hvi hasta niveles normales. No obstante, la regresi\u00f3n de la hvi no se corresponde con una completa normalizaci\u00f3n de los patrones de expresi\u00f3n g\u00e9nico y proteico, permaneciendo alterados numerosos genes y prote\u00ednas. De esta forma, el an\u00e1lisis de las respuestas terap\u00e9uticas en la huella molecular en \u00f3rganos diana podr\u00eda dar lugar a la identificaci\u00f3n de mediadores claves en el proceso hipertr\u00f3fico, y abrir nuevas v\u00edas de de estudio para el desarrollo de mejores terapias cardioprotectoras en el marco de la hipertensi\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulaci\u00f3n farmacol\u00f3gica de la expresi\u00f3n g\u00e9nica y prot\u00e9ica en \u00f3rganos diana durante la hipertensi\u00f3n arterial<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulaci\u00f3n farmacol\u00f3gica de la expresi\u00f3n g\u00e9nica y prot\u00e9ica en \u00f3rganos diana durante la hipertensi\u00f3n arterial <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alberto Lazaro Fern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/05\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Egido De Los Rios<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Oya otero <\/li>\n<li>Juan  Antonio Lopez del olmo (vocal)<\/li>\n<li> Tu\u00f1on fernandez Jos\u00e9 Luis (vocal)<\/li>\n<li>Alberto Tejedor Jorge (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alberto Lazaro Fern\u00e1ndez La hipertensi\u00f3n arterial es la enfermedad cr\u00f3nica mas frecuente en el mundo desarrollado, y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[6530,1601,1323],"tags":[171151,15545,5119,139079,2097,171152],"class_list":["post-79790","post","type-post","status-publish","format-standard","hentry","category-farmacologia-experimental","category-patologia-cardiovascular","category-patologia-experimental","tag-alberto-lazaro-fernandez","tag-alberto-tejedor-jorge","tag-jesus-egido-de-los-rios","tag-juan-antonio-lopez-del-olmo","tag-manuel-oya-otero","tag-tunon-fernandez-jose-luis"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79790","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=79790"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79790\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=79790"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=79790"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=79790"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}