{"id":79812,"date":"2006-05-05T00:00:00","date_gmt":"2006-05-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/funcion-de-alfacp4-en-la-carcinogenesis-pulmonar-evaluacion-de-su-posible-papel-como-gen-supresor-de-tumores\/"},"modified":"2006-05-05T00:00:00","modified_gmt":"2006-05-05T00:00:00","slug":"funcion-de-alfacp4-en-la-carcinogenesis-pulmonar-evaluacion-de-su-posible-papel-como-gen-supresor-de-tumores","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia-clinica\/funcion-de-alfacp4-en-la-carcinogenesis-pulmonar-evaluacion-de-su-posible-papel-como-gen-supresor-de-tumores\/","title":{"rendered":"Funcion de alfacp4 en la carcinogenesis pulmonar evaluacion de su posible papel como gen supresor de tumores"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Zafira Casta\u00f1o  Corsino <\/strong><\/h2>\n<p>Role of alphacp-4, a putative tumor suppressor gene,in lung c\u00e1ncer. Zafira casta\u00f1o corsino faculty of science university of navarra, 2006 acp-4 is an rna binding protein coded by a gene at 3p21. It has been proposed that acp-4 may function as a \u00ablung tumor suppressor gene. Lack of acp-4 expression is freq\u00ed\u00bcent in highly proliferative lung tumors. This activity is not observed in acp-4a, a splice variant whose expression is apparently normal in lung tumors. The aims of this study were to eval\u00faate the relationship between acp-4 expression and survival of patients affected with lung c\u00e1ncer, study the induction of acp-4 expression by p53, eval\u00faate the efrect of acp-4 and acp-4a in the tumorigenic capacity of lung c\u00e1ncer cells and study the proliferation status of h1299 lung c\u00e1ncer cell unes when they are treated with chemotherapic drugs and acp-4 is expressed. No relationship was found between acp-4 expression and survival. By inducing damages in the dna we could see that acp-4 expression was induced by r>53. Employing transient transfection in different lung c\u00e1ncer cell lines as well as infection with recombinant retroviruses in h1299 cells acp-4 and acp-4a expression was induced. A different subcellular localization of acp-4 and acp-4a was observed that could account for their different effects on cell proliferation, cell cycle arrest in g2\/m, suppression of anchorage-independent growth in soft agar and reduction of the invasi\u00f3n capacity. Finally, tumorigenicity of h1299 cells in nude mi ce was greatly inhibited by expression of acp-4. In conclusi\u00f3n, expression of acp-4 is induced by p53 and can inhibit proliferation and tumorig\u00e9nesis of h1299 cells by inducing cell cycle arrest. These results suggest that acp-4 inactivation may be an important event in the early stages of lung carcinogenesis.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Funcion de alfacp4 en la carcinogenesis pulmonar evaluacion de su posible papel como gen supresor de tumores<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Funcion de alfacp4 en la carcinogenesis pulmonar evaluacion de su posible papel como gen supresor de tumores <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Zafira Casta\u00f1o  Corsino <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/05\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rub\u00e9n Pio Os\u00e9s<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: xose ramon Garcia bustero <\/li>\n<li>Miguel angel Molina (vocal)<\/li>\n<li>montserrat S\u00e1nchez c\u00e9spedes (vocal)<\/li>\n<li>Francisco Javier S\u00e1ez castresana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Zafira Casta\u00f1o Corsino Role of alphacp-4, a putative tumor suppressor gene,in lung c\u00e1ncer. Zafira casta\u00f1o corsino faculty [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,17749,347],"tags":[18296,171195,75587,76110,171194,171193],"class_list":["post-79812","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-navarra","category-oncologia-clinica","tag-francisco-javier-saez-castresana","tag-miguel-angel-molina","tag-montserrat-sanchez-cespedes","tag-ruben-pio-oses","tag-xose-ramon-garcia-bustero","tag-zafira-castano-corsino"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79812","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=79812"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79812\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=79812"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=79812"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=79812"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}