{"id":79821,"date":"2006-08-05T00:00:00","date_gmt":"2006-08-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-dependientes-e-independientes-de-la-ca2-estimulados-a-traves-de-la-va%c2%ada-no-gmpc\/"},"modified":"2006-08-05T00:00:00","modified_gmt":"2006-08-05T00:00:00","slug":"mecanismos-dependientes-e-independientes-de-la-ca2-estimulados-a-traves-de-la-va%c2%ada-no-gmpc","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-dependientes-e-independientes-de-la-ca2-estimulados-a-traves-de-la-va%c2%ada-no-gmpc\/","title":{"rendered":"Mecanismos dependientes e independientes de la [ca2+], estimulados a trav\u00e9s de la v\u00edano\/gmpc"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Zaragoz\u00e1 Arn\u00e1ez <\/strong><\/h2>\n<p>Tras el nacimiento debe producirse una brusca transici\u00f3n de la placenta al pulm\u00f3n como \u00f3rgano encargado del intercambio gaseoso. Esta transici\u00f3n requiere una dr\u00e1stica reducci\u00f3n de las resistencias vasculares pulmonares, que de no producirse puede conducir al desarrollo de la hipertensi\u00f3n pulmonar persistente neonatal. Este s\u00edndrome se ha relacionado con una disminuci\u00f3n de la actividad vasodilatadora de la v\u00eda del \u00f3xido n\u00edtrico\/gmpc y\/o con un aumento de la actividad vasocontrictora del tromboxano a2 y\/o de la endotelina-1.    el objetivo general de esta tesis doctoral es analizar los mecanismos, y en particular la dependencia de la [ca2+]i, en la vasodilataci\u00f3n inducida por v\u00edas dependientes e independientes de no\/gmpc en arterias pulmonares y mesent\u00e9ricas de lechones reci\u00e9n nacidos y su dependencia del est\u00edmulo vasoconstrictor.     las principales conclusiones obtenidas son:     1,- la vasodilataci\u00f3n tras la activaci\u00f3n de la v\u00eda del no\/gmpc presenta una mayor selectividad por el territorio sist\u00e9mico que por el pulmonar. Estas diferencias no son consecuencia de una menor efectividad para reducir la [ca2+]i, sino de una menor sensibilidad del m\u00fasculo liso vascular pulmonar a la disminuci\u00f3n de la [ca2+]i.     2,- la vasodilataci\u00f3n inducida por la v\u00eda no\/gmpc es consecuencia de una reducci\u00f3n de la [ca2+]i mediada a trav\u00e9s de la activaci\u00f3n de la serca y una disminuci\u00f3n de la sensibilidad de las prote\u00ednas contr\u00e1ctiles al ca2+.     3,- de entre las distintas v\u00edas de vasodilataci\u00f3n estudiadas, ninguna present\u00f3 una selectividad por el territorio pulmonar. Tanto la actividad de la adenilil ciclasa como la inhibici\u00f3n de la rho cinasa resultaron ser los mecanismos m\u00e1s eficaces para producir una vasodilataci\u00f3n pulmonar.     4,- la participaci\u00f3n de los mecanismos dependientes e independientes de ca2+ en la respuesta vasodilatadora inducida por la v\u00eda no\/gmpc var\u00eda dependiendo del est\u00edmulo vasoconstrictor.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos dependientes e independientes de la [ca2+], estimulados a trav\u00e9s de la v\u00edano\/gmpc<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos dependientes e independientes de la [ca2+], estimulados a trav\u00e9s de la v\u00edano\/gmpc <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Zaragoz\u00e1 Arn\u00e1ez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/05\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Luis Tamargo Men\u00e9ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Castilo Garc\u00eda benito del <\/li>\n<li>Jos\u00e9 Jim\u00e9nez mart\u00edn (vocal)<\/li>\n<li>amalia Ubeda pascual (vocal)<\/li>\n<li>cecilio \u00e1lamo gonz\u00e1lez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Zaragoz\u00e1 Arn\u00e1ez Tras el nacimiento debe producirse una brusca transici\u00f3n de la placenta al pulm\u00f3n como [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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