{"id":79881,"date":"2006-12-05T00:00:00","date_gmt":"2006-12-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/trasplante-autologo-de-progenitores-hematopoyeticos-como-opcion-terapeutica-en-la-esclerosis-multiple\/"},"modified":"2006-12-05T00:00:00","modified_gmt":"2006-12-05T00:00:00","slug":"trasplante-autologo-de-progenitores-hematopoyeticos-como-opcion-terapeutica-en-la-esclerosis-multiple","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/trasplante-autologo-de-progenitores-hematopoyeticos-como-opcion-terapeutica-en-la-esclerosis-multiple\/","title":{"rendered":"Trasplante aut\u00f3logo de  progenitores hematopoy\u00e9ticos como opci\u00f3n terap\u00e9utica en la esclerosis m\u00faltiple"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Yolanda Blanco Morgado <\/strong><\/h2>\n<p>Introducci\u00f3n  a esclerosis m\u00faltiple (em) es  una enfermedad autoinmune mediada por c\u00e9lulas cd4+ autorreactivas frente a ant\u00edgenos miel\u00ednicos severamente discapacitante que afecta fundamentalmente a una poblaci\u00f3n joven y para la que no se dispone de ning\u00fan tratamiento capaz de detener la progresi\u00f3n de la discapacidad. gracias a los resultados experimentales con modelos animales que demuestran que el trasplante aut\u00f3logo es capaz de conseguir la remisi\u00f3n de la enfermedad autoinmune al igual que el alog\u00e9nico, pero con mucha menor toxicidad, el trasplante aut\u00f3logo de progenitores hematopoy\u00e9ticos (taph) se ha erigido en los \u00faltimos a\u00f1os como una opci\u00f3n viable para el tratamiento de enfermedades autoinmunes en humanos. Las bases racionales del taph en la em se fundamentan en la ablaci\u00f3n del sistema inmune y la erradicaci\u00f3n de las c\u00e9lulas autorreactivas, y la posterior reconstituci\u00f3n de un nuevo sistema inmune tolerante con los autoant\u00edgenos.  hip\u00f3tesis y objetivos  la tolerancia inmune tras el taph deber\u00eda conllevar un descenso en la actividad inflamatoria inmunomediada con una mejor\u00eda en el curso cl\u00ednico y radiol\u00f3gico de los pacientes asociado a un descenso demarcadores biol\u00f3gicos de actividad inflamatoria implicados en la patogenia de la em. Para ello, analizamos la evoluci\u00f3n de los niveles de mmp-9, de bdnf, la reconstituci\u00f3n inmune, y el perfil de secreci\u00f3n de citocinas. Asimismo, estudiamos la influencia del polimorfismo funcional bdnf-val66met en la capacidad de secreci\u00f3n de bdnf por las c\u00e9lulas inmunes, as \u00ed como en la susceptibilidad a padecer em o en la severidad de la misma.  resultados  14 pacientes con em agresiva resistente a la terapia convencional fueron sometidos a un taph. La mortalidad del procedimiento fue del 0% y no se produjo ning\u00fan evento t\u00f3xico grave.  tras una mediana de seguimiento de 3 a\u00f1os se produjo un gran descenso en la tasa de brotes y la probabilidad de permanecer libre<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Trasplante aut\u00f3logo de  progenitores hematopoy\u00e9ticos como opci\u00f3n terap\u00e9utica en la esclerosis m\u00faltiple<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Trasplante aut\u00f3logo de  progenitores hematopoy\u00e9ticos como opci\u00f3n terap\u00e9utica en la esclerosis m\u00faltiple <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Yolanda Blanco Morgado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/05\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Albert Saiz Hinerejos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Garc\u00eda merino Juan  Antonio <\/li>\n<li>alfredo Rodr\u00edguez-antig\u00ed\u00bcedad zarranz (vocal)<\/li>\n<li>jaume Roquer gonzalez (vocal)<\/li>\n<li>m. carmen Mart\u00ednez mu\u00f1oz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Yolanda Blanco Morgado Introducci\u00f3n a esclerosis m\u00faltiple (em) es una enfermedad autoinmune mediada por c\u00e9lulas cd4+ autorreactivas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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