{"id":79885,"date":"2006-12-05T00:00:00","date_gmt":"2006-12-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evidencia-de-la-eficacia-de-farmacos-anti-tnf-alfa-en-el-tratamiento-de-espondilitis-anquilosante\/"},"modified":"2006-12-05T00:00:00","modified_gmt":"2006-12-05T00:00:00","slug":"evidencia-de-la-eficacia-de-farmacos-anti-tnf-alfa-en-el-tratamiento-de-espondilitis-anquilosante","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/reumatologia\/evidencia-de-la-eficacia-de-farmacos-anti-tnf-alfa-en-el-tratamiento-de-espondilitis-anquilosante\/","title":{"rendered":"Evidencia de la eficacia de f\u00e1rmacos anti-tnf alfa en el tratamiento de espondilitis anquilosante"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Montilla Salas Juan  Manuel <\/strong><\/h2>\n<p>Objetivo     establecer la evidencia de los estudios cl\u00ednicos sobre la eficacia de las terapias anti-tnf alfa para el tratamiento de la espondilitis anquilosante (ea).  m\u00e9todos     se realiz\u00f3 una b\u00fasqueda con los diferentes f\u00e1rmacos anti-ntf alfa actualmente utilizados en terapia de la espondilitis anquilosante (infiximab, etanercept y adalimumab). La revisi\u00f3n bibliogr\u00e1fica se realiz\u00f3 en medline, embase y la librer\u00eda cochrane para los estudios controlados y randomizados publicados hasta 1-enero-2005. Tambi\u00e9n se realiz\u00f3 una b\u00fasqueda secundaria en los abstracts y comunicaciones realizados a congresos y simposiums   celebrados antes de la fecha l\u00edmite. Para la selecci\u00f3n para el meta-an\u00e1lisis, los estudios deb\u00edan cumplir los siguientes criterios de selecci\u00f3n:     1,- estudios cl\u00ednicos controlados y randomizados comparando una terapia anti-tnf alfa frente a placebo.     2,- diagn\u00f3stico de espondilitis anguilosante realizado seg\u00fan los criterios de new york modificados.     3,- evaluaci\u00f3n de la respuesta con los criterios del grupo asas (al menos 20%).  resultados     seis estudios fueron seleccionados para la realizaci\u00f3n del meta-an\u00e1lisis (braun 2002, gorman 2002, davis 2003, brandt 2003, calin 2004, van der heijde 2004) y consideramos de alta calidad  metodol\u00f3gica, que reunieron un total de 779 pacientes: 452 pacientes del grupo de tratamiento (antitnf alfa) y 3 27 pacientes en el grupo control-placebo. Los resultados procedentes de los diferentes estudios, inclu\u00edan periodos de seguimiento entre 6 y 24 semanas (corto plazo). En el grupo de tratamiento con terapia anti-tnf alfa, la tasa de mejor\u00eda cl\u00ednica a corto plazo, seg\u00fan criterios de respuesta asas20 fue del 61,50% de los pacientes y del 22,63% de los pacientes en el grupo placebo. El beneficio relativo (rb) fue 2,73 (95% ic 2,20 a 3,38), favorable al grupo de tratamiento. El nnt (n\u00famero necesario para tratar) fue 3 (ic 95% 4 a 2).  conclusion     las terapias anti-tn<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evidencia de la eficacia de f\u00e1rmacos anti-tnf alfa en el tratamiento de espondilitis anquilosante<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evidencia de la eficacia de f\u00e1rmacos anti-tnf alfa en el tratamiento de espondilitis anquilosante <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Montilla Salas Juan  Manuel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/05\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Collantes Estevez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez guijo <\/li>\n<li>veronica Perez gujio (vocal)<\/li>\n<li>Miguel Caracuel ruiz (vocal)<\/li>\n<li>Juan Mulero mendoza (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Montilla Salas Juan Manuel Objetivo establecer la evidencia de los estudios cl\u00ednicos sobre la eficacia de las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[973,877],"tags":[2277,97947,49975,171337,1935,171338],"class_list":["post-79885","post","type-post","status-publish","format-standard","hentry","category-cordoba","category-reumatologia","tag-eduardo-collantes-estevez","tag-juan-mulero-mendoza","tag-miguel-caracuel-ruiz","tag-montilla-salas-juan-manuel","tag-pedro-sanchez-guijo","tag-veronica-perez-gujio"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79885","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=79885"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79885\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=79885"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=79885"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=79885"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}