{"id":79917,"date":"2006-12-05T00:00:00","date_gmt":"2006-12-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cytosolic-nadph-reoxidation-in-kluyveromyces-lactis\/"},"modified":"2006-12-05T00:00:00","modified_gmt":"2006-12-05T00:00:00","slug":"cytosolic-nadph-reoxidation-in-kluyveromyces-lactis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/cytosolic-nadph-reoxidation-in-kluyveromyces-lactis\/","title":{"rendered":"Cytosolic nadph reoxidation in kluyveromyces lactis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Nuria Tarr\u00edo Y\u00e1\u00f1ez <\/strong><\/h2>\n<p>En levaduras, estudios previos indicaban que kluyveomyces lactis, levadura preferentemente respiradora, posee unos mecanismos m\u00e1s eficaces para reoxidar el nadph generado por la ruta de las pentosas fosfato que la levadura convencional saccharmyces cerevisiae, levadura preferentemente fermentadora. Este hecho permite un mayor uso de la ruta de las pentosas fosfato para la catabolizaci\u00f3n de la glucosa en k. Lactis, en relaci\u00f3n con s. Cerevisae. La tesis se centra en el estudio de los mecanismos de reoxidaci\u00f3n del nadph en k. Lactis. Fundamentalmente: rutas de bios\u00edntesis, ciclos transhidrogenasa, rutas de respuesta a estr\u00e9s oxidativo y deshidrogenasas alternativas externas. en relaci\u00f3n a las rutas biosint\u00e9ticas y ciclos transhidrogenasa, se han hecho estudios del transcriptoma mediante arrays heter\u00f3logos, comparando una cepa silvestre de k. Lactis con un mutante (rag2) obligado a catabolizar toda la glucosa a trav\u00e9s de la ruta de las pentosas fosfato, de este modo se genera un aumento de nadph citos\u00f3lico. En el an\u00e1lisis de expresi\u00f3n no se encuentran diferencias importantes entre la cepa silvestre y el mutante ambos cultivados en glucosa, lo que indica que el uso de la ruta de las pentosas fosfato es muy elevado en la cepa silvestre. Las mayores diferencias han sido encontradas en la comparaci\u00f3n del transcriptoma en el mutante rag2 cultivado en glucosa frente a la fructosa, a pesar de que no se observa incremento de ninguna ruta de bios\u00edntesis consumidora de nadph ni de ning\u00fan ciclo transhidrogenasa que convierta el nadph en nadh para que este \u00faltimo pueda ser respirado o fermentado, aparece un incremento en algunos genes de respuesta a estr\u00e9s oxidativo, cuyas enzimas centrales usan nadph como cofactor. Adem\u00e1s, se han realizado estudios de expresi\u00f3n g\u00e9nica y ensayos de actividad enzim\u00e1tica que han demostrado que el ciclo citoplasm\u00e1tico mediado por las glutamato deshidrogenasas no est\u00e1 implicado en la reoxidaci\u00f3n del nadph en el mutante rag2 c<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cytosolic nadph reoxidation in kluyveromyces lactis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cytosolic nadph reoxidation in kluyveromyces lactis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Nuria Tarr\u00edo Y\u00e1\u00f1ez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 A coru\u00f1a<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/05\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Gonzalez Siso Mar\u00eda  Isabel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Cerdan villanueva Mar\u00eda  esperanza <\/li>\n<li>j. Heinisch jurgen (vocal)<\/li>\n<li>\u00e1ngel Dom\u00ednguez olavarri (vocal)<\/li>\n<li>arnaldo Videira (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nuria Tarr\u00edo Y\u00e1\u00f1ez En levaduras, estudios previos indicaban que kluyveomyces lactis, levadura preferentemente respiradora, posee unos mecanismos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[18576,36483,35],"tags":[9537,171389,163405,83318,171388,171387],"class_list":["post-79917","post","type-post","status-publish","format-standard","hentry","category-a-coruna","category-biologia-molecular","category-ciencias-de-la-vida","tag-angel-dominguez-olavarri","tag-arnaldo-videira","tag-cerdan-villanueva-maria-esperanza","tag-gonzalez-siso-maria-isabel","tag-j-heinisch-jurgen","tag-nuria-tarrio-yanez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79917","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=79917"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79917\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=79917"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=79917"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=79917"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}