{"id":79945,"date":"2018-03-09T23:25:50","date_gmt":"2018-03-09T23:25:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/validacion-de-seroteca-variacion-de-la-inmunorreactividad-de-psa-total-y-psa-libre-serico-bajo-varias-temperaturas-de-congelacion-y-tiempo\/"},"modified":"2018-03-09T23:25:50","modified_gmt":"2018-03-09T23:25:50","slug":"validacion-de-seroteca-variacion-de-la-inmunorreactividad-de-psa-total-y-psa-libre-serico-bajo-varias-temperaturas-de-congelacion-y-tiempo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cirugia-urologica\/validacion-de-seroteca-variacion-de-la-inmunorreactividad-de-psa-total-y-psa-libre-serico-bajo-varias-temperaturas-de-congelacion-y-tiempo\/","title":{"rendered":"Validaci\u00f3n de seroteca: variaci\u00f3n de la inmunorreactividad de psa total y psa libre s\u00e9rico bajo varias temperaturas de congelaci\u00f3n y tiempo."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Trivez Boned Miguel Angel <\/strong><\/h2>\n<p>Introducci\u00f3n el psa es un marcador tumoral con alta sensibilidad y baja especificidad. Se han investigado diferentes m\u00e9todos para aumentar la especificidad del psa, aunque estas investigaciones precisan validaci\u00f3n prospectiva que dificulta su aplicaci\u00f3n a la pr\u00e1ctica cl\u00ednica. como soluci\u00f3n a este problema surge el concepto de seroteca: almacenamiento de muestras de sueros a temperatura adecuada durante un tiempo determinado, posibilitando as\u00ed la realizaci\u00f3n de investigaciones con las ventajas de los estudios retrospectivos. con la intenci\u00f3n de mejorar el rendimiento de los m\u00e9todos diagn\u00f3sticos de uso cl\u00ednico en el c\u00e1ncer de pr\u00f3stata, se desarrollo en el a\u00f1o 1997 en el hospital universitario miguel servet una seroteca que almacena en la actualidad aproximadamente el suero de 3000 pacientes a temperaturas de &#8211; 40\u00c2\u00ba c y &#8211; 80\u00c2\u00ba c. hip\u00f3tesis no existen diferencias en la inmunorreactividad de psa total y psa libre durante un a\u00f1o de almacenamiento a &#8211; 40 ni a &#8211; 80\u00c2\u00ba c. objetivos 1. Objetivo principal: validar la seroteca, como base de estudios retrospectivos de la aplicaci\u00f3n de psa total, psa libre, ratio de psa libre\/total y su relaci\u00f3n con otras variables cl\u00ednicas en el diagn\u00f3stico precoz, estadificaci\u00f3n y tratamiento del c\u00e1ncer de pr\u00f3stata. 2. Objetivos secundarios: a). Analizar la variaci\u00f3n de la inmunorreactividad de psa total, psa libre y ratio psa libre\/total en sueros congelados a &#8211; 40\u00c2\u00ba c y -80\u00c2\u00ba c durante 1 a\u00f1o. B). Analizar si existen diferencias entre la variaci\u00f3n de la inmunorreactividad del psa total, psa libre y ratio psa libre\/total y la anatom\u00eda patol\u00f3gica de la biopsia prost\u00e1tica realizada. material y metodos muestras de 239 pacientes consecutivos con tacto rectal sospechoso de c\u00e1ncer de pr\u00f3stata y\/o psa > 4 ng \/ml que ingresaron para ser sometidos a una biopsia prost\u00e1tica. *variables descriptivas: edad, tacto rectal (\u00absospechoso\u00bb o \u00abno sospechoso\u00bb). *variables predictivas: determinaci\u00f3n inicial de p<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Validaci\u00f3n de seroteca: variaci\u00f3n de la inmunorreactividad de psa total y psa libre s\u00e9rico bajo varias temperaturas de congelaci\u00f3n y tiempo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Validaci\u00f3n de seroteca: variaci\u00f3n de la inmunorreactividad de psa total y psa libre s\u00e9rico bajo varias temperaturas de congelaci\u00f3n y tiempo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Trivez Boned Miguel Angel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/05\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Allepuz Losa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alejandro Tres sanchez <\/li>\n<li>milagros Bernal perez (vocal)<\/li>\n<li>joaqu\u00edn Carballido rodr\u00edguez (vocal)<\/li>\n<li> Garcia de jalon comet angel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Trivez Boned Miguel Angel Introducci\u00f3n el psa es un marcador tumoral con alta sensibilidad y baja especificidad. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1533,13610],"tags":[27351,171441,46630,14430,28778,171440],"class_list":["post-79945","post","type-post","status-publish","format-standard","hentry","category-cirugia-urologica","category-zaragoza","tag-alejandro-tres-sanchez","tag-carlos-allepuz-losa","tag-garcia-de-jalon-comet-angel","tag-joaquin-carballido-rodriguez","tag-milagros-bernal-perez","tag-trivez-boned-miguel-angel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79945","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=79945"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79945\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=79945"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=79945"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=79945"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}