{"id":79958,"date":"2018-03-09T23:25:50","date_gmt":"2018-03-09T23:25:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-tratamientos-hormonales-cronicos-sobre-el-envejecimiento-cutaneo\/"},"modified":"2018-03-09T23:25:50","modified_gmt":"2018-03-09T23:25:50","slug":"efecto-de-tratamientos-hormonales-cronicos-sobre-el-envejecimiento-cutaneo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-tratamientos-hormonales-cronicos-sobre-el-envejecimiento-cutaneo\/","title":{"rendered":"Efecto de tratamientos hormonales cr\u00f3nicos sobre el envejecimiento cut\u00e1neo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Fern\u00e1ndez-tresguerres Centeno <\/strong><\/h2>\n<p>Los objetivos del estudio fueron:      1,- analizar el efecto del envejecimiento sobre los distintos componentes dela piel (epidermis, dermis, hipodermis y celularidad d\u00e9rmica) desde el punto de vista histol\u00f3gico e histomorfometrico.     2,-investigar el metabolismo de los queratinocitos en cultivo primario, procedentes de animales de distintas edades, analizando diferentes par\u00e1metros de estr\u00e9s oxidativo y apopt\u00f3sis.     3,- analizar el efecto de la de la ovariectom\u00eda sobre los par\u00e1metros anteriormente mencionados.     4,- estudiar los efectos ejercidos por diferentes tratamientos hormonales cr\u00f3nicos (gh, melatonina, estr\u00f3genos y fitoestr\u00f3genos) sobre los par\u00e1metros histol\u00f3gicos e histomorfom\u00e9tricos modificados con la edad.     5,- estudiar los efectos de los diferentes tratamientos hormonales cr\u00f3nicos (gh, melatonina, estr\u00f3genos y fitoestr\u00f3genos) sobre los par\u00e1metros modificados con la edad de estr\u00e9s oxidativo y apoptosis en los cultivos primarios de queratinocitos.     el envejecimiento produce alteraciones cut\u00e1neas tanto histol\u00f3gicas como metab\u00f3licas. Histol\u00f3gicamente se aprecia una disminuci\u00f3n del grosor epid\u00e9rmico, un aumento importante del grosor del tejido celular subcut\u00e1neo y una disminuci\u00f3n de la celularidad d\u00e9rmica. El grosor de la dermis no parece sufrir cambios con la edad, pero \u00e9sta aparece m\u00e1s desestructurada y laxa, con haces de col\u00e1geno m\u00e1s largos y estrechos. En el cultivo de queratinocitos los par\u00e1metros relacionados con el estr\u00e9s oxidativo se incrementan con el envejecimiento, produci\u00e9ndose un aumento de lpo y de co. con respecto a los niveles de apoptosis se produce un aumento de nucleosomas, caspasa 3 y caspasas 8, mientras que los niveles de bcls disminuyen con la edad. Las hembras intactas mantienen cierta producci\u00f3n estrog\u00e9nica ov\u00e1rica hasta edades avanzadas. Por ello algunas de estas alteraciones son m\u00e1s evidentes en los animales machos y en las hembras ovariectomizadas, sugiriendo un posibl<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de tratamientos hormonales cr\u00f3nicos sobre el envejecimiento cut\u00e1neo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de tratamientos hormonales cr\u00f3nicos sobre el envejecimiento cut\u00e1neo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Fern\u00e1ndez-tresguerres Centeno <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/05\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>tresguerres Hern\u00e1ndez Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: a. L\u00f3pez calderon <\/li>\n<li>d. Acu\u00f1a (vocal)<\/li>\n<li>j. Vi\u00e1 (vocal)<\/li>\n<li>g. Escames (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Fern\u00e1ndez-tresguerres Centeno Los objetivos del estudio fueron: 1,- analizar el efecto del envejecimiento sobre los distintos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[171466,171465,171467,171469,171468,93393],"class_list":["post-79958","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-a-lopez-calderon","tag-ana-fernandez-tresguerres-centeno","tag-d-acuna","tag-g-escames","tag-j-via","tag-tresguerres-hernandez-fernandez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79958","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=79958"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79958\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=79958"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=79958"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=79958"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}