{"id":79970,"date":"2018-03-09T23:25:50","date_gmt":"2018-03-09T23:25:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/early-steps-regulating-proliferation-and-activation-in-macrophages\/"},"modified":"2018-03-09T23:25:50","modified_gmt":"2018-03-09T23:25:50","slug":"early-steps-regulating-proliferation-and-activation-in-macrophages","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/early-steps-regulating-proliferation-and-activation-in-macrophages\/","title":{"rendered":"Early steps regulating proliferation and activation in macrophages"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ester Sanchez Tillo <\/strong><\/h2>\n<p>Los macr\u00f3fagos son c\u00e9lulas que tienen un papel cr\u00edtico en la respuesta inmunitaria. En presencia del factor de crecimiento m-csf proliferan y si se a\u00f1ade el lipopolisac\u00e1rido bacteriano (lps) que induce su activaci\u00f3n se bloquea la proliferaci\u00f3n. La mapk erk es necesaria tanto para la proliferaci\u00f3n como para la activaci\u00f3n de los macr\u00f3fagos. Sin embargo, su cin\u00e9tica de fosforilaci\u00f3n es diferente. En respuesta a factores de proliferaci\u00f3n, la fosforilaci\u00f3n de erk se inicia pronto y dura un tiempo muy limitado. En respuesta al lps, la fosforilaci\u00f3n de erk se inicia m\u00e1s tarde y dura m\u00e1s tiempo. De esta manera, la respuesta del macr\u00f3fago depender\u00e1 del inicio y extensi\u00f3n de la activaci\u00f3n de erk. La fosfatasa mkp-1 es la que defosforila a las mapks y su cin\u00e9tica de inducci\u00f3n es paralela a la desactivaci\u00f3n de las mapks. La inducci\u00f3n por m-csf o lps est\u00e1 mediada por pkc.     nuestros estudios en cultivos primarios de macr\u00f3fagos murinos obtenidos de la m\u00e9dula \u00f3sea, demuestran que la expresi\u00f3n de mkp-1 por ambos est\u00edmulos es dependiente de la activaci\u00f3n de la quinasa raf-1 y de la interacci\u00f3n de \u00e9sta con pkc. La cin\u00e9tica de activaci\u00f3n de erk es paralela a la activaci\u00f3n de raf-1 y de mek-1\/2. El uso de inhbidores espec\u00edficos y de rna de interferencia, ha demostrado que la activaci\u00f3n de erk cuando se induce la proliferaci\u00f3n es totalmente dependiente de raf-1 mientras que los est\u00edmulos activadores pueden utilizar v\u00edas alternas. La inhibici\u00f3n de la actividad raf-1 genera una parada del ciclo celular en g1 provocada por un aumento de la expresi\u00f3n de inhibidores de las quinasas dependientes de ciclina (cdks), p21walf1 y p24kip1. Con respecto a la activaci\u00f3n, no se observan defectos en la expresi\u00f3n de citocinas proinflamatorias y en la inducci\u00f3n de la sinatasa del \u00f3xido n\u00edtrico.     la inducci\u00f3n de mkp-1 tanto por m-csf como por lps, no est\u00e1 mediada por erk o p38. Sin embargo, la inhibici\u00f3n de jnk bloquea la expresi\u00f3n de mkp-1. Co<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Early steps regulating proliferation and activation in macrophages<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Early steps regulating proliferation and activation in macrophages <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ester Sanchez Tillo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/05\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Celada Cotarelo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: cayetano Gonz\u00e1lez <\/li>\n<li> Zubiaga elordieta Ana Mar\u00eda (vocal)<\/li>\n<li>purificacion Mu\u00f1oz canoves (vocal)<\/li>\n<li>jordi Xaus pey (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ester Sanchez Tillo Los macr\u00f3fagos son c\u00e9lulas que tienen un papel cr\u00edtico en la respuesta inmunitaria. En [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,1737],"tags":[10671,126690,171487,101097,46030,64026],"class_list":["post-79970","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-inmunologia","tag-antonio-celada-cotarelo","tag-cayetano-gonzalez","tag-ester-sanchez-tillo","tag-jordi-xaus-pey","tag-purificacion-munoz-canoves","tag-zubiaga-elordieta-ana-maria"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79970","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=79970"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79970\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=79970"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=79970"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=79970"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}