{"id":79992,"date":"2018-03-09T23:25:54","date_gmt":"2018-03-09T23:25:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-estres-oxidativo-y-nitrosativo-en-la-patogenia-de-la-hepatitis-c-implicacion-de-las-protea%c2%adnas-va%c2%adricas-ns5a-y-core-del-vhc\/"},"modified":"2018-03-09T23:25:54","modified_gmt":"2018-03-09T23:25:54","slug":"papel-del-estres-oxidativo-y-nitrosativo-en-la-patogenia-de-la-hepatitis-c-implicacion-de-las-protea%c2%adnas-va%c2%adricas-ns5a-y-core-del-vhc","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/gastroenterologia\/papel-del-estres-oxidativo-y-nitrosativo-en-la-patogenia-de-la-hepatitis-c-implicacion-de-las-protea%c2%adnas-va%c2%adricas-ns5a-y-core-del-vhc\/","title":{"rendered":"Papel del estr\u00e9s oxidativo y nitrosativo en la patogenia de la hepatitis c. implicaci\u00f3n de las prote\u00ednas v\u00edricas ns5a y core del vhc"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pilar Gonz\u00e1lez P\u00e9rez <\/strong><\/h2>\n<p>La hepatitis c es la causa m\u00e1s frecuente de morbilidad y mortalidad relacionadas con el h\u00edgado en el mundo y representa un problema de salud p\u00fablica importante. Sin embargo, el mecanismo mediante el cual el virus de la hepatitis c (vhc) causa da\u00f1o hep\u00e1tico no est\u00e1 totalmente establecido, si bien podr\u00edan estar implicados la respuesta inmune frente a los hepatocitos infectados as\u00ed como los efectos citop\u00e1ticos directos de las prote\u00ednas del virus. Estudios previos indican la posible implicaci\u00f3n de la existencia de estr\u00e9s oxidativo en la patogenia de la enfermedad. As\u00ed, la infecci\u00f3n por vhc se caracteriza por un incremento en la concentraci\u00f3n circulante de especies reactivas de ox\u00edgeno (eros) y de nitr\u00f3geno (erns).  entre los principales mecanismos de defensa frente a las eros y erns se encuentra el incremento de la expresi\u00f3n de las enzimas antioxidantes. A este respecto, se ha descrito un aumento de la concentraci\u00f3n de arnm de la sod mitocondrial (sod-mn) en c\u00e9lulas mononucleares perif\u00e9ricas, si bien dicho incremento no se observa en el h\u00edgado, lo que sugiere que este \u00f3rgano estar\u00eda menos protegido contra el da\u00f1o oxidativo.  algunas prote\u00ednas v\u00edricas est\u00e1n implicadas directamente en los mecanismos patog\u00e9nicos de la enfermedad. A ese respecto, se ha descrito la participaci\u00f3n de la prote\u00edna estructural core y de la no estructural ns5a en la inducci\u00f3n de dicho estr\u00e9s oxidativo.  a pesar de conocerse la implicaci\u00f3n del estr\u00e9s oxidativo en el desarrollo de la hepatitis c y la contribuci\u00f3n de las prote\u00ednas core y ns5a del vhc en dicho proceso, es pr\u00e1cticamente inexistente la informaci\u00f3n referente a la naturaleza de las distintas eros y erns generadas as\u00ed como su patr\u00f3n temporal de aparici\u00f3n, su repercusi\u00f3n en la activaci\u00f3n de la expresi\u00f3n g\u00e9nica de onsi, la aparici\u00f3n de da\u00f1o oxidativo celular y las modificaciones existentes en la capacidad antioxidante enzim\u00e1tica y no enzim\u00e1tica hep\u00e1tica, por lo que en el presente trabajo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del estr\u00e9s oxidativo y nitrosativo en la patogenia de la hepatitis c. implicaci\u00f3n de las prote\u00ednas v\u00edricas ns5a y core del vhc<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del estr\u00e9s oxidativo y nitrosativo en la patogenia de la hepatitis c. implicaci\u00f3n de las prote\u00ednas v\u00edricas ns5a y core del vhc <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pilar Gonz\u00e1lez P\u00e9rez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/05\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Victoria Garc\u00eda Mediavilla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: javier Gonz\u00e1lez gallego <\/li>\n<li>carmelo Garc\u00eda monz\u00f3n (vocal)<\/li>\n<li>carmen Villares Garc\u00eda (vocal)<\/li>\n<li>Luis Fontana gallego (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pilar Gonz\u00e1lez P\u00e9rez La hepatitis c es la causa m\u00e1s frecuente de morbilidad y mortalidad relacionadas con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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