{"id":79994,"date":"2018-03-09T23:25:54","date_gmt":"2018-03-09T23:25:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-rechazo-primario-en-el-trasplante-de-islotes-pancreaticos\/"},"modified":"2018-03-09T23:25:54","modified_gmt":"2018-03-09T23:25:54","slug":"estudio-del-rechazo-primario-en-el-trasplante-de-islotes-pancreaticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-rechazo-primario-en-el-trasplante-de-islotes-pancreaticos\/","title":{"rendered":"Estudio del rechazo primario en el trasplante de islotes pancre\u00e1ticos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 M. Balibrea Del Castillo <\/strong><\/h2>\n<p>El trasplante de islotes pancre\u00e1ticos (tip) es una alternativa terap\u00e9utica para la diabetes mellitus tipo 1 (dm) en desarrollo. Sus resultados cl\u00ednicos han experimentando una espectacular mejor\u00eda tras la introducci\u00f3n de nuevos protocolos de inmunosupresi\u00f3n libres de corticoides que incluyen, entre otros, f\u00e1rmacos como el tacrolimus (fk-506) a bajas dosis.     uno de los principales problemas del tip es el llamado rechazo o disfunci\u00f3n durante las primeras horas\/d\u00edas tras el implante. Este fen\u00f3meno est\u00e1 producido por los efectos de la respuesta inflamatoria inmediata sobrelos islotes, reduciendo su n\u00famero dram\u00e1ticamente. Durante el rechazo primario los fen\u00f3menos de liberaci\u00f3n de mediadores inflamatorios, generaci\u00f3n de estr\u00e9s oxidativo y activaci\u00f3n de la apoptosis son las bases de su fisiopatolog\u00eda.     en este trabajo se han estudiado tales procesos en islotes humanos y de rata tras reproducir las condiciones del rechazo primario al estimularlos con citocinas proinflamatorias. Dado que el efecto por el que el fk-506 protege a los islotes o es bien conocido, se estudia adem\u00e1s si la adici\u00f3n al medio de bajas dosis del f\u00e1rmaco var\u00eda los fen\u00f3menos fisiopatol\u00f3gicos antes rese\u00f1ados y el contenido de insulina de los islotes.     la estimulaci\u00f3n de los islotes con il-1, ambos o lipopolisacr\u00e1diso desencaden\u00f3 la liberaci\u00f3n masiva de mediadores inflamatorios y la generaci\u00f3n de estr\u00e9s oxidativo; activ\u00f3 la apopotisis y disminuci\u00f3n el contenido de insulina. El empleo de fk-506 a bajas dosis consigui\u00f3 revertir tales efectos de manera significativa sin afectar negativamente a los islotes.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del rechazo primario en el trasplante de islotes pancre\u00e1ticos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del rechazo primario en el trasplante de islotes pancre\u00e1ticos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 M. Balibrea Del Castillo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/05\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Balibrea  Cantero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Bl\u00e1zquez fern\u00e1ndez <\/li>\n<li>Alberto Gomez alonso (vocal)<\/li>\n<li>Francisco Lozano sanchez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 M. Balibrea Del Castillo El trasplante de islotes pancre\u00e1ticos (tip) es una alternativa terap\u00e9utica para la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[141,1],"tags":[9244,3180,9873,4963,171531],"class_list":["post-79994","post","type-post","status-publish","format-standard","hentry","category-cirugia","category-sin-categoria","tag-alberto-gomez-alonso","tag-enrique-blazquez-fernandez","tag-francisco-lozano-sanchez","tag-jose-luis-balibrea-cantero","tag-jose-m-balibrea-del-castillo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79994","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=79994"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/79994\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=79994"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=79994"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=79994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}