{"id":80025,"date":"2018-03-09T23:25:54","date_gmt":"2018-03-09T23:25:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-de-quinolizinio-y-cationes-analogos-por-reaccion-de-metatesis\/"},"modified":"2018-03-09T23:25:54","modified_gmt":"2018-03-09T23:25:54","slug":"sa%c2%adntesis-de-quinolizinio-y-cationes-analogos-por-reaccion-de-metatesis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/compuestos-heterociclicos\/sa%c2%adntesis-de-quinolizinio-y-cationes-analogos-por-reaccion-de-metatesis\/","title":{"rendered":"S\u00edntesis de quinolizinio y cationes an\u00e1logos por reacci\u00f3n de met\u00e1tesis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana N\u00fa\u00f1ez S\u00e1nchez <\/strong><\/h2>\n<p>El quinolizinio es el representante m\u00e1s sencillo de los cationes heteroarom\u00e1ticos que presentan un nitr\u00f3geno cuaternario en posici\u00f3n cabeza de puente. Este n\u00facleo forma parte de la estructura de importantes alcaloides que tienen actividad biol\u00f3gica de inter\u00e9s como la coralina, proterberinas o sempervirina. Nuestro grupo de investigaci\u00f3n se ha centrado en el estudio del comportamiento como intercalantes de adn y antiproliferativos de distintos crom\u00f3foros que contienen este n\u00facleo en su estructura, comprobando que la sustituci\u00f3n de estos sistemas modifica la actividad. Sin embargo su s\u00edntesis y funcionalizaci\u00f3n presenta limitaciones. En la presente tesis se ha abordado este problema buscando una metodolog\u00eda general que permita mayor diversidad funcional, utilizando la reacci\u00f3n de mat\u00e1tesis de cierre de anillo. a trav\u00e9s de n-alquilaciones con triflatos de alquenilo sobre alfa-vinilazinas se ha llevado a cabo la s\u00edntesis di\u00e9nicos sobre los que se ha aplicado la reacci\u00f3n de met\u00e1tesis, utilizando los catalizadores de grubbs y de hoveyda de segunda generaci\u00f3n obteni\u00e9ndose una serie de 3,4-dihidroquinolizinios son con funcionalidades diversas, adem\u00e1s de sistemas bic\u00edclicos de distinto tama\u00f1o. Tambi\u00e9n se han preparado 2-vinil-3,4-dihidroquinolizinios a partir de triflatos de n-alquinil-alfa-vinilazinios, y 1-vinil-3,4-dihidroquinolinios a partir de n-butenil-alfa-alquilazinios, usando el catalizador de hoveyda en atm\u00f3sfera de etileno. La s\u00edntesis de benzo- y nalftoquinolizinios se ha compuesto con una metodolog\u00eda alternativa utilizando alfa-estiril-n-vinilazinios, demostr\u00e1ndose de nuevo en los procesos de met\u00e1tesis implicados, la mayor estabilidad t\u00e9rmica del catalizador de hoveyda. Finalmente, se han mejorado los m\u00e9todos de oxidaci\u00f3n de 3,4-dihidroquinolizinios para la s\u00edntesis de quinolizinios, mediante la utilizaci\u00f3n de pd\/c a 200\u00c2\u00ba c y en ausencia de disolvente.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis de quinolizinio y cationes an\u00e1logos por reacci\u00f3n de met\u00e1tesis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis de quinolizinio y cationes an\u00e1logos por reacci\u00f3n de met\u00e1tesis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana N\u00fa\u00f1ez S\u00e1nchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/05\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Jos\u00e9 Vaquero L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: benito Alcaide ala\u00f1on <\/li>\n<li>Javier Perez castells (vocal)<\/li>\n<li>Jos\u00e9 Luis Mascare\u00f1as cid (vocal)<\/li>\n<li>Juan  Carlos Carretero gonz\u00e1lvez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana N\u00fa\u00f1ez S\u00e1nchez El quinolizinio es el representante m\u00e1s sencillo de los cationes heteroarom\u00e1ticos que presentan un [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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