{"id":80034,"date":"2018-03-09T23:25:54","date_gmt":"2018-03-09T23:25:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-expresion-del-hla-g-en-pacientes-infectados-por-el-vih-y-de-las-causas-que-la-modulan\/"},"modified":"2018-03-09T23:25:54","modified_gmt":"2018-03-09T23:25:54","slug":"estudio-de-la-expresion-del-hla-g-en-pacientes-infectados-por-el-vih-y-de-las-causas-que-la-modulan","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cordoba\/estudio-de-la-expresion-del-hla-g-en-pacientes-infectados-por-el-vih-y-de-las-causas-que-la-modulan\/","title":{"rendered":"Estudio de la expresi\u00f3n del hla-g en pacientes infectados por el vih y de las causas que la modulan"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Clara Natera Kindelan <\/strong><\/h2>\n<p>El inicio de la era targa ha supuesto un paso de gran importancia en la evoluci\u00f3n de la infecci\u00f3n por el vih. Con los nuevos tratamientos, se consigue suprimir de forma sostenida la replicaci\u00f3n viral pero lo que a\u00fan no se ha conseguido es eliminar el virus de los reservorios. Por otro lado, el hla-g es una mol\u00e9cula de histocompatibilidad del cph clase i, se ha demostrado que induce tolerancia inmunol\u00f3gica y se asocia a numerosas patolog\u00edas como infecciones virales e incluso infecci\u00f3n por vih donde su expresi\u00f3n de encuentra aumentada.     nos propusimos confirmar el aumento de esta mol\u00e9cula en los pacientes infectados, analizar las causas que no lo podr\u00edan justificar y analizar el papel del propio tratamiento sobre la expresi\u00f3n del hla-g.     para ello dise\u00f1amos un estudio donde comparamos su expresi\u00f3n en enfermos infectados y tratados, infectados sin tratamiento y sanos. Posteriormente, analizamos su evoluci\u00f3n tras una interrupci\u00f3n programada de tratamiento y tras la modificaci\u00f3n del r\u00e9gimen terap\u00e9utico seg\u00fan los resultados previos obtenidos.     concluimos que el hla-g est\u00e1 aumentado en pacientes con infecci\u00f3n vih en tratamiento, que el grupo farmacol\u00f3gico asociado a este efecto es el de los itian y que al sustituirlo por otro grupo o simplemente dejar el tratamiento el efecto se revierte.     estos hechos son de especial importancia pues indican que el tratamiento al tiempo que suprime la replicaci\u00f3n viral contribuye, por un fen\u00f3meno de tolerancia inmune, a perpetuar el virus en los reservorios.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la expresi\u00f3n del hla-g en pacientes infectados por el vih y de las causas que la modulan<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la expresi\u00f3n del hla-g en pacientes infectados por el vih y de las causas que la modulan <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Clara Natera Kindelan <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/05\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mar\u00eda Kindelan Jaquotot<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Pe\u00f1a Martinez <\/li>\n<li> Lozano de le\u00f3n-naranjo Fernando (vocal)<\/li>\n<li>Juli\u00e1n de la Torre cisneros (vocal)<\/li>\n<li>elisa Vidal verdu (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Clara Natera Kindelan El inicio de la era targa ha supuesto un paso de gran importancia en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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