{"id":80080,"date":"2018-03-09T23:25:58","date_gmt":"2018-03-09T23:25:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/dinamica-de-la-actina-y-trafico-de-membranas-asociado-al-complejo-de-golgi-papel-regulador-de-rhoa-rac1-y-cdc42\/"},"modified":"2018-03-09T23:25:58","modified_gmt":"2018-03-09T23:25:58","slug":"dinamica-de-la-actina-y-trafico-de-membranas-asociado-al-complejo-de-golgi-papel-regulador-de-rhoa-rac1-y-cdc42","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/citologia\/dinamica-de-la-actina-y-trafico-de-membranas-asociado-al-complejo-de-golgi-papel-regulador-de-rhoa-rac1-y-cdc42\/","title":{"rendered":"Din\u00e1mica de la actina y tr\u00e1fico de membranas asociado al complejo de golgi: papel regulador de rhoa, rac1 y cdc42"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Matas Guadix Olga Bel\u00e9n <\/strong><\/h2>\n<p>El trabajo llevado a cabo en esta tesis contribuye a esclarecer la relaci\u00f3n morfo-funcional entre la actina y el complejo de golgi. Estudios previos del laboratorio ponen de manifiesto que la actina regula no s\u00f3lo la posici\u00f3n y morfolog\u00eda del complejo de golgi en la c\u00e9lula (di campli et al., 1999; valderrama et al., 1998) sino tambi\u00e9n el transporte de prote\u00ednas desde el cg al ret\u00edculo endoplasm\u00e1tico (transporte retr\u00f3grado; valderrama et al., 2001). Un trabajo m\u00e1s reciente de nuestro grupo muestra a la rho gtpasa cdc42 como el componente molecular que regula los efectos del citoesqueleto de actina sobre el cg (luna et al., 2002). En este trabajo se pone de manifiesto que cdc42 se localiza en el cg y su activaci\u00f3n comporta su acumulaci\u00f3n en los laterales de las cistemas de este org\u00e1nulo. Adem\u00e1s, la forma activa de cdc42 (gtp-cdc42) regula negativamente el transporte retr\u00f3grado de prote\u00ednas actuando a trav\u00e9s de n-wasp y del complejo multiproteico arp2\/3. de estos resultados concluimos que la v\u00eda de se\u00f1alizaci\u00f3n cdc42-n-wasp-arp2\/3 que gobierna la nucleaci\u00f3n de polimerizaci\u00f3n de actina a nivel de la membrana plasm\u00e1tica (pollard y borisy, 2003) tambi\u00e9n es funcional a nivel del complejo de golgi. En esta tesis nos planteamos estudiar si al igual que ocurre con cdc42, sus efectores n-wasp y arp2\/3 se localizan tambi\u00e9n el cg. La presencia de todos los componentes necesarios para la polimerizaci\u00f3n de actina en este org\u00e1nulo es requisito necesario para demostrar que efectivamente las membranas del cg pueden polimerizar actina.     otro de los objetivos de esta tesis era determinar de forma definitiva si rac1 y rhoa regulaban tambi\u00e9n alguna de las etapas de la din\u00e1mica de membranas en la v\u00eda secretora temprana. Estas dos prote\u00edna junto con cdc42 son los miembros mejor conocidos de la familia de las rho gtpasas. Todas ellas regulan, aunque de diferente forma, la organizaci\u00f3n del citoesqueleto de actina (etienne-manneville y hall, 2002). En la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Din\u00e1mica de la actina y tr\u00e1fico de membranas asociado al complejo de golgi: papel regulador de rhoa, rac1 y cdc42<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Din\u00e1mica de la actina y tr\u00e1fico de membranas asociado al complejo de golgi: papel regulador de rhoa, rac1 y cdc42 <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Matas Guadix Olga Bel\u00e9n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/05\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> <\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Oriol Bachs Valldeneu <\/li>\n<li>Montserrat Vilella (vocal)<\/li>\n<li>Jaime Renau Piqueras (vocal)<\/li>\n<li>Mar\u00eda  Del Mar Malagon Poyato (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Matas Guadix Olga Bel\u00e9n El trabajo llevado a cabo en esta tesis contribuye a esclarecer la relaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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