{"id":80144,"date":"1999-03-06T00:00:00","date_gmt":"1999-03-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-potencial-genotoxico-del-omeprazol-y-su-capacidad-inductora-sobre-la-actividad-cyp1a2\/"},"modified":"1999-03-06T00:00:00","modified_gmt":"1999-03-06T00:00:00","slug":"estudio-del-potencial-genotoxico-del-omeprazol-y-su-capacidad-inductora-sobre-la-actividad-cyp1a2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-del-potencial-genotoxico-del-omeprazol-y-su-capacidad-inductora-sobre-la-actividad-cyp1a2\/","title":{"rendered":"Estudio del potencial genotoxico del omeprazol y su capacidad inductora sobre la actividad cyp1a2."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Val Perez <\/strong><\/h2>\n<p>Omeprazol, de la familia de los imidaz\u00f3licos, es el primer representante de una nueva familia de f\u00e1rmacos: los inhibidores de la bomba \u00e1cida g\u00e1strica o enzima atpasa h+-k+, responsable de la secreci\u00f3n de cih por la c\u00e9lula parietal g\u00e1strica. De este modo consigue reducir la secreci\u00f3n \u00e1cida g\u00e1strica, tanto de la basal como de la inducida tras est\u00edmulo.  estudios en ratas, con altas dosis de omeprazol y durante prolongados periodos de tiempo, han identificado tumores carcinoides en la mucosa g\u00e1strica, asociados a un bloque de la secreci\u00f3n \u00e1cida g\u00e1strica. Este hecho llev\u00f3 al planteamiento de un mejor conocimiento de lo que realmente suced\u00eda en su aplicaci\u00f3n a humanos.  otro hecho de gran importancia, y tambi\u00e9n centro de debate, fue la publicaci\u00f3n de la posibilidad del omeprazol de inducir (in vitro e in vivo) una forma del citocromo p-450: el subgrupo ia2 en el h\u00edgado humano.  te\u00f3ricamente este hecho podr\u00eda estimular la activaci\u00f3n de procarcin\u00f3genos y, por lo tanto, incrementar el riesgo de carcinog\u00e9nesis, dado que las subfamilias p-450 ia1 y ia2 son las responsables de la conversi\u00f3n de mol\u00e9culas procarcinog\u00e9nicas, como los hidrocarburos polic\u00edclicos, amidas y aminas arom\u00e1ticas, a metabolitos que pueden causar carcinog\u00e9nesis y\/o mutag\u00e9nesis.  el objetivo de la tesis es detectar si el tratamiento con omeprazol en voluntarios sanos, produce o no un incremento del riesgo de exposici\u00f3n a carcin\u00f3genos, para ello se incluyeron en el estudio 33 voluntarios sanos y se les administraron 20 mg diarios de omeprazol durante 14 d\u00edas, estudi\u00e1ndose antes y despu\u00e9s las aberraciones cromos\u00f3micas, los intercambios entre mol\u00e9culas hermanas, los micron\u00facleos, el \u00edndice de proliferaci\u00f3n celular y el \u00edndice mit\u00f3tico en linfocitos de sangre perif\u00e9rica y los tio\u00e9teres urinarios y la mutagenicidad urinaria en la orina de los voluntarios. para estudiar la posible inducci\u00f3n del citocromo p450 1a2 por omeprazol<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del potencial genotoxico del omeprazol y su capacidad inductora sobre la actividad cyp1a2.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del potencial genotoxico del omeprazol y su capacidad inductora sobre la actividad cyp1a2. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Val Perez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/06\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Blanca Sinues Porta<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: blanca Conde guerri <\/li>\n<li>teresa Ferro delgado (vocal)<\/li>\n<li>Jos\u00e9 Miguel Garcia sagredo (vocal)<\/li>\n<li>Elena Sinues porta (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Val Perez Omeprazol, de la familia de los imidaz\u00f3licos, es el primer representante de una nueva [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[8901,9,189,156,17648,13610],"tags":[13207,45754,104755,13755,171797,104754],"class_list":["post-80144","post","type-post","status-publish","format-standard","hentry","category-carcinogenesis","category-ciencias-medicas","category-farmacodinamia","category-patologia","category-procesos-metabolicos-de-los-farmacos","category-zaragoza","tag-blanca-conde-guerri","tag-blanca-sinues-porta","tag-elena-sinues-porta","tag-jose-miguel-garcia-sagredo","tag-marta-val-perez","tag-teresa-ferro-delgado"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/80144","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=80144"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/80144\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=80144"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=80144"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=80144"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}