{"id":80167,"date":"1999-10-06T00:00:00","date_gmt":"1999-10-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-relacion-entre-el-citocromo-p4501a2-y-psicofarmacos-2\/"},"modified":"1999-10-06T00:00:00","modified_gmt":"1999-10-06T00:00:00","slug":"estudio-de-la-relacion-entre-el-citocromo-p4501a2-y-psicofarmacos-2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-relacion-entre-el-citocromo-p4501a2-y-psicofarmacos-2\/","title":{"rendered":"Estudio de la relaci\u00f3n entre el citocromo p4501a2 y psicofarmacos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Ramos Rodr\u00edguez Sara Isabel <\/strong><\/h2>\n<p>Los citocromos p450 realizan la malyor parte del metabolismo oxidativo en los seres vivios. Entre ellos, el cyp1a2 es importante toxicol\u00f3gicamente al transformar sustancias qu\u00edmicas medioambientales (algunas de ellas incluidas en aditivos y conservantes alimenticios, en carnes cocinadas a la brasa, as\u00ed como en el humo del tabaco) en intermediarios t\u00f3xicos. Esta enzima est\u00e1 sujeta a inhibici\u00f3n e inducci\u00f3n, incluso por algunos de los sustratos anteriores, lo que produce una valla variabilidad intra e interindividual en su activida dmetab\u00f3lica. La cafe\u00edna es sustrato del cyp1a2, siendo usada para evaluar esa actividad metab\u00f3lica en humanos.  en esta tesis doctoral se utilizaron diversas t\u00e9cnicas de cromatograf\u00eda l\u00edquida de alta presi\u00f3n (hplc), para la determinaci\u00f3n de cafe\u00edna y metabolitos, en orina, plasma y saliva, en voluntarios sanos. Se evalu\u00f3 la actividad del cyp1a2 usando par\u00e1metros farmacocin\u00e9ticos y ratios metab\u00f3licos basados en al cafe\u00edna, y se estudi\u00f3 la influencia de factores como el sexto y el tabaco sobre esa actividad, comprob\u00e1ndose que era significativamente menor en mujeres no fumadoras. Posteriormente se estudi\u00f3 la relaci\u00f3n entre el cyp1a2 y los antipsic\u00f3ticos elozapina olanzpaina y tiroidazina en pacientes psiqui\u00e1tricos en monoterapia con estos psicof\u00e1rmacos. Se observ\u00f3 una estrecha relaci\u00f3n entre el cyp1a2 y los dos primeros f\u00e1rmacos, indicando el importante papel de eta enzima en sus metabolismos. Del mismo modo, se observ\u00f3 una potente interacci\u00f3n entre el antidepresivo fluvoxamina y el antipsic\u00f3tico tioridazina, con la posible participaci\u00f3n del cyp1a2 en ella. Por lo tanto se ha de tener en cuenta el riesgo de interacci\u00f3n entre sustratos de la misma enzima, as\u00ed como aquellos factores que pudieran influir en la actividad del cyp1a2 (sexo, tabaco, consumo de caf\u00e9), a la hora de prescribir estos psicof\u00e1rmacos, para evitar en los pacientes el fracaso terap\u00e9utico, efecto secundarios ind<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la relaci\u00f3n entre el citocromo p4501a2 y psicofarmacos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la relaci\u00f3n entre el citocromo p4501a2 y psicofarmacos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Ramos Rodr\u00edguez Sara Isabel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/06\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Carrillo Norte Juan  Antonio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Guti\u00e9rrez merino <\/li>\n<li>Jos\u00e9 Mar\u00eda Ladero quesada (vocal)<\/li>\n<li>Jes\u00fas Marin lopez (vocal)<\/li>\n<li>Francisco Jos\u00e9 Vaz leal (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ramos Rodr\u00edguez Sara Isabel Los citocromos p450 realizan la malyor parte del metabolismo oxidativo en los seres [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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