{"id":80226,"date":"2018-03-10T00:03:54","date_gmt":"2018-03-10T00:03:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/carnitina-octanoiltransferasa-de-rata-un-gen-modelo-para-el-estudio-del-trans-splicing\/"},"modified":"2018-03-10T00:03:54","modified_gmt":"2018-03-10T00:03:54","slug":"carnitina-octanoiltransferasa-de-rata-un-gen-modelo-para-el-estudio-del-trans-splicing","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/carnitina-octanoiltransferasa-de-rata-un-gen-modelo-para-el-estudio-del-trans-splicing\/","title":{"rendered":"Carnitina octanoiltransferasa de rata: un gen modelo para el estudio del trans-splicing"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Concha Caudevilla Asensio <\/strong><\/h2>\n<p>La carnitina octanoiltransferasa (cot) es la enzima responsable de la exportaci\u00f3n de aciles-coa del peroxisoma al citoplasma, ejerciendo as\u00ed un papel importante en la regulaci\u00f3n de la oxidaci\u00f3n peroxisomal de \u00e1cidos grasos. El gen cot en rata es de copia \u00fanica sin embargo da lugar a la formaci\u00f3n de tres transcritos maduros. El procesamiento de los pre-mrnas de cot tiene lugar, de forma natural, por cis y por trans-splicing. El transcrito m\u00e1s ligero se produce por cis-splicing y presenta la organizaci\u00f3n ex\u00f3nica ya descrita. Los otros dos transcritos de mayor tama\u00f1o son producto de una reacci\u00f3n de trans-splicing y contienen, respectivamente, el ex\u00f3n 2 y los exones 2 y 3 repetidos. Esto permite la posible formaci\u00f3n de nuevas proteinas cot. El procesamiento de los pre-mrnas de cot de rata por trans-splicing puede ser explicado por la presencia de secuencias ex\u00f3nicas (cajas ese) en el ex\u00f3n 2 que le convierten en un buen dador de splicing in vivo e in vitro. Este proceso de trans-splicing observado en la rata no ha sido detectado en otros mam\u00edferos analizados. La causa de este hecho radica en la secuencia de nucle\u00f3tidos de una de las cajas ese conservada en todas las especies analizadas a excepci\u00f3n de la rata. Estudios de microinyecci\u00f3n de pre-mrnas truncados en n\u00facleo de c\u00e9lulas en cultivo, demuestran la capacidad del ex\u00f3n 2 de cot para dar trans-splicing con otros genes distintos de la cot permitiendo as\u00ed la generaci\u00f3n de nuevas prote\u00ednas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Carnitina octanoiltransferasa de rata: un gen modelo para el estudio del trans-splicing<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Carnitina octanoiltransferasa de rata: un gen modelo para el estudio del trans-splicing <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Concha Caudevilla Asensio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/06\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fausto Garcia Hegardt<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Aguilar piera <\/li>\n<li>adolf Graessmann (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Concha Caudevilla Asensio La carnitina octanoiltransferasa (cot) es la enzima responsable de la exportaci\u00f3n de aciles-coa del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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