{"id":80252,"date":"2018-03-10T00:03:59","date_gmt":"2018-03-10T00:03:59","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-oxido-nitrico-y-del-anion-superoxido-en-la-esofagitis-cronica-experimental-inducida-con-acido-y-pepsina\/"},"modified":"2018-03-10T00:03:59","modified_gmt":"2018-03-10T00:03:59","slug":"papel-del-oxido-nitrico-y-del-anion-superoxido-en-la-esofagitis-cronica-experimental-inducida-con-acido-y-pepsina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-del-oxido-nitrico-y-del-anion-superoxido-en-la-esofagitis-cronica-experimental-inducida-con-acido-y-pepsina\/","title":{"rendered":"Papel del oxido nitrico y del anion superoxido en la esofagitis cronica experimental inducida con acido y pepsina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Isabel Fiteni Mera <\/strong><\/h2>\n<p>La enfermedad por reflujo gastro-esof\u00e1gico adem\u00e1s de ser muy frecuente, encierra un importante potencial de gravedad en sus complicaciones. No se conocen demasiado los mecanismos de defensa de la mucosa esof\u00e1gica frente al \u00e1cido y pepsina regulando el flujo mucoso as\u00ed como el mecanismo de adaptaci\u00f3n. el ani\u00f3n super\u00f3xido es el principal radical libre involucrado en la lesi\u00f3n con exposici\u00f3n \u00fanica de la mucosa esof\u00e1gica a acido y pepsina. En nuestro trabajo nos planteamos describir el papel del no, ya que puede desempe\u00f1ar funciones defensivas y tambien lesivas, y el del ani\u00f3n super\u00f3xido en la agresi\u00f3n cr\u00f3nica con acido y pepsina que se asemejaria bastante a lo que ocurre en la esofagitis humana.  para esto producimos una esofagitis cr\u00f3nica en conejos siguiendo un modelo descrito por nuestro grupo para conseguir dos tipos diferenciados de lesi\u00f3n; de bajo y de alto grado, con perfusiones de \u00e1cido y pepsina a trav\u00e9s de una sonda colocada en el es\u00f3fago proximal. Con perfusiones de 30 min cada 12 h durante 7 dias se consiguen lesiones de bajo grado similar a la esofagitis leve humana y con perfusiones de 45 min\/12 h durante 5 dias se consigue una esofagitis de alto grado similar a las m\u00e1s graves en el humano. Para estudiar el papel del no se administr\u00f3 en un grupo l-nna que inhibe su s\u00edntesis y en otro nitroprusiato para aumentar su concentraci\u00f3n al mismo tiempo que se produce la esofagitis con las pefusiones. Para valorar el ani\u00f3n super\u00f3xido se administr\u00f3 a un grupo super\u00f3xido dismutasa que elimina el ani\u00f3n producido. Adem\u00e1s de cuantificar la lesi\u00f3n en cada grupo medimos la actividad de las enzimas no-sintasa y su isoforma constitutiva(cnos) en la mucosa, la producci\u00f3n de ani\u00f3n super\u00f3xido en celulas de cada grupo asi como la produccion de peroxinitritos.  en la esofagitis de bajo grado, la mucosa responde a la agresi\u00f3n \u00e1cido-peptica con un aumento de la enzima nos(principalmente cnos) como mecanismo de def<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del oxido nitrico y del anion superoxido en la esofagitis cronica experimental inducida con acido y pepsina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del oxido nitrico y del anion superoxido en la esofagitis cronica experimental inducida con acido y pepsina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Isabel Fiteni Mera <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/06\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Lanas Arbeloa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: gabriel Guill\u00e9n mart\u00ednez <\/li>\n<li>oriol Bulbena (vocal)<\/li>\n<li>ricardo Sainz samitier (vocal)<\/li>\n<li>Fernando Borda celaya (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Isabel Fiteni Mera La enfermedad por reflujo gastro-esof\u00e1gico adem\u00e1s de ser muy frecuente, encierra un importante potencial [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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