{"id":80350,"date":"1999-08-07T00:00:00","date_gmt":"1999-08-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-mediante-modelizacion-molecular-de-la-reactividad-de-ciclopropapirroloindolas-en-medio-acido\/"},"modified":"1999-08-07T00:00:00","modified_gmt":"1999-08-07T00:00:00","slug":"analisis-mediante-modelizacion-molecular-de-la-reactividad-de-ciclopropapirroloindolas-en-medio-acido","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/analisis-mediante-modelizacion-molecular-de-la-reactividad-de-ciclopropapirroloindolas-en-medio-acido\/","title":{"rendered":"An\u00e1lisis mediante modelizaci\u00f3n molecular de la reactividad de ciclopropapirroloindolas en medio \u00e1cido"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  L\u00f3pez Mosquera M. Bel\u00e9n <\/strong><\/h2>\n<p>El presente trabajo ha tenido como objetivo fundamental la aplicaci\u00f3n de la modelizaci\u00f3n molecular al dise\u00f1o de an\u00e1logos del potente agente antitumoral cc-1065. De modo que permita ofrecer nuevas soluciones a diferentes aspectos relacionados con la actividad de estos compuestos.  en primer lugar, se aplicaron estas t\u00e9cnicas para analizar la relaci\u00f3n entre la energ\u00eda molecular y la geometr\u00eda de diferentes compuestos con esqueleto ind\u00f3lico, de manera que fue posible el dise\u00f1o de un an\u00e1logo cuya s\u00edntesis alcance un rendimiento adecuado.  a continuaci\u00f3n, se realiz\u00f3 un estudio global de diversos an\u00e1logos con un mismo tipo de esqueleto base de ciclopropapirroloindolona, encaminado al postulado e interpretaci\u00f3n del mecanismo de la reacci\u00f3n de solv\u00f3lisis de estos compuestos en medio \u00e1cido.  por \u00faltimo, se llevaron a cabo c\u00e1lculos te\u00f3ricos que permitieron predecir la posibilidad de un tipo de reacci\u00f3n a nivel molecular que minimizase los efectos secundarios de estos f\u00e1rmacos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis mediante modelizaci\u00f3n molecular de la reactividad de ciclopropapirroloindolas en medio \u00e1cido<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis mediante modelizaci\u00f3n molecular de la reactividad de ciclopropapirroloindolas en medio \u00e1cido <\/li>\n<li><strong>Autor:<\/strong>\u00a0  L\u00f3pez Mosquera M. Bel\u00e9n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 A coru\u00f1a<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/07\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel \u00e1ngel Maestro Saavedra<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel \u00e1ngel Peric\u00ed\u00a0s brondo <\/li>\n<li>bernardo Herradon garcia (vocal)<\/li>\n<li>Antonio Palenzuela lopez (vocal)<\/li>\n<li>ricardo Mosquera castro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de L\u00f3pez Mosquera M. Bel\u00e9n El presente trabajo ha tenido como objetivo fundamental la aplicaci\u00f3n de la modelizaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[18576,1412,239,17,416],"tags":[2844,31808,172102,61246,19695,39518],"class_list":["post-80350","post","type-post","status-publish","format-standard","hentry","category-a-coruna","category-compuestos-heterociclicos","category-mecanismos-de-las-reacciones-organicas","category-quimica","category-quimica-organica","tag-antonio-palenzuela-lopez","tag-bernardo-herradon-garcia","tag-lopez-mosquera-m-belen","tag-miguel-angel-maestro-saavedra","tag-miguel-angel-perici-s-brondo","tag-ricardo-mosquera-castro"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/80350","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=80350"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/80350\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=80350"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=80350"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=80350"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}