{"id":8039,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/alteracion-del-complejo-mayor-de-histocompatibilidad-de-clase-i-y-en-la-diabetes-tipo-i\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"alteracion-del-complejo-mayor-de-histocompatibilidad-de-clase-i-y-en-la-diabetes-tipo-i","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/alteracion-del-complejo-mayor-de-histocompatibilidad-de-clase-i-y-en-la-diabetes-tipo-i\/","title":{"rendered":"Alteracion del complejo mayor de histocompatibilidad de clase i y en la diabetes tipo i."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Pinies Raposo Jos\u00e9 Antonio <\/strong><\/h2>\n<p>En la etiolog\u00eda de la diabetes mellitus tipo i (dm i) participan diferentes factores ambientales y geneticos existiendo entre estos ultimos un gen predominante, el complejo mayor de histocompatibilidad (mhc).  recientemente se ha descrito una presentacion defectuosa de las moleculas del mhc de clase i en las celulas presentadoras de antigenos (apcs) de pacientes con dm tipo i, que podria alterar la tolerancia a lo propio.  mediante la produccion de anticuerpos monoclonales (mabs) creados contra los antigenos de superficie e intracelulares de linfocitos de gemelos monocigotos discordantes para dm tipo i (del gemelo no diabetico) se creo un mab que reconocio el dimero de cadenas alfa del mhc de clase i. Este dimero se expreso deficientemente en la superficie de linfocitos del gemelo diabetico versus su gemelo identico no diabetico. Estos defectos explicarian como la asociacion con el mhc confiere susceptibilidad para presentar dm tipo i.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteracion del complejo mayor de histocompatibilidad de clase i y en la diabetes tipo i.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteracion del complejo mayor de histocompatibilidad de clase i y en la diabetes tipo i. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Pinies Raposo Jos\u00e9 Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Vazquez Garcia Jos\u00e9 Antonio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Enrique Bl\u00e1zquez Fern\u00e1ndez <\/li>\n<li>Jos\u00e9 Antonio Amado Se\u00f1aris (vocal)<\/li>\n<li>Fernando Merino Ni\u00f1o (vocal)<\/li>\n<li>Ramon Gomis Barbera (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pinies Raposo Jos\u00e9 Antonio En la etiolog\u00eda de la diabetes mellitus tipo i (dm i) participan diferentes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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