{"id":80394,"date":"2018-03-10T00:04:07","date_gmt":"2018-03-10T00:04:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modificaciones-de-la-vasoconstriccion-pulmonar-hipoxica-por-la-endotoxemia\/"},"modified":"2018-03-10T00:04:07","modified_gmt":"2018-03-10T00:04:07","slug":"modificaciones-de-la-vasoconstriccion-pulmonar-hipoxica-por-la-endotoxemia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modificaciones-de-la-vasoconstriccion-pulmonar-hipoxica-por-la-endotoxemia\/","title":{"rendered":"Modificaciones de la vasoconstriccion pulmonar hipoxica por la endotoxemia."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Isusi Nieto <\/strong><\/h2>\n<p>En un m\u00f3dulo experimental de circulaci\u00f3n pulmonar aislada en ratas sometidas a endotoxemia mediante la inyecci\u00f3n de 20 mg\/kg de endotoxina de escherichia coli 6 horas antes de iniciar la fase experimental analizamos la presi\u00f3n arterial pulmonar en estado basal y la vasorreactividad pulmonar a la hipoxia. Encontramos que en la endotoxemia se produce un leve y no significativo aumento de la presi\u00f3n arterial pulmonar basal y, sobretodo, una gran potenciaci\u00f3n de la vasoconstricci\u00f3n pulmonar hip\u00f3xica que se mantiene invariable a lo largo de todo el est\u00edmulo hip\u00f3xico. Estas respuestas no varian al inducir la inhibici\u00f3n de la cilcooxigenasa con indometacina, lo cual hace pensar que las prostaglandinas no son las responsables de estos efectos. La inhibici\u00f3n de las sintetasas de \u00f3xido n\u00edtrico eleva ligeramente la presi\u00f3n arterial pulmonar basal y potencia a\u00fan m\u00e1s la respuesta hip\u00f3xica y el bloqueo de la guanilato ciclasa aumenta la presi\u00f3n arterial pulmonar basal y disminuye la respuesta hip\u00f3xica.  estos resultados sugieren que en la endotoxemia hay un incremento de la producci\u00f3n de \u00f3xido n\u00edtrico pulmonar que actuaria como freno fisiol\u00f3gico tendente a contrarrestar la hipertensi\u00f3n pulmonar que se produce en estas situaciones.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modificaciones de la vasoconstriccion pulmonar hipoxica por la endotoxemia.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modificaciones de la vasoconstriccion pulmonar hipoxica por la endotoxemia. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Isusi Nieto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/07\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Casta\u00f1eda Casado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez Garc\u00eda <\/li>\n<li>alfonso Velasco alonso (vocal)<\/li>\n<li>guillermo Ramos seisdedos (vocal)<\/li>\n<li>Juan Gomez rubi (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Isusi Nieto En un m\u00f3dulo experimental de circulaci\u00f3n pulmonar aislada en ratas sometidas a endotoxemia mediante [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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