{"id":80405,"date":"2018-03-10T00:04:07","date_gmt":"2018-03-10T00:04:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/enfermedades-peroxisomales-estudio-en-celulas-mononucleares-de-metabolitos-implicados-en-las-vias-metabolicas-del-peroxisoma\/"},"modified":"2018-03-10T00:04:07","modified_gmt":"2018-03-10T00:04:07","slug":"enfermedades-peroxisomales-estudio-en-celulas-mononucleares-de-metabolitos-implicados-en-las-vias-metabolicas-del-peroxisoma","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/enfermedades-peroxisomales-estudio-en-celulas-mononucleares-de-metabolitos-implicados-en-las-vias-metabolicas-del-peroxisoma\/","title":{"rendered":"Enfermedades peroxisomales: estudio en celulas mononucleares de metabolitos implicados en las vias metabolicas del peroxisoma."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Montserrat Ruiz Sales <\/strong><\/h2>\n<p>El diagnostico bioqu\u00edmico de las enfermedades peroxiosomales se realiza, en primera instancia, a trav\u00e9s de los metabolitos acumulados o deficientes en dichas enfermedades: para ello se requieren diversos espec\u00edmenes: plasma\/suero, fibroblastos de piel cultivados y eritrocitos. El objetivo principal de esta tesis ha consistido en el estudio de dichos metabolitos en c\u00e9lulas mononucleares con el fin de utilizarlas com tipo celular alternativo. El estudio de perfil de los acidos grasos saturados, monoinsaturados y poliinsaturados de cadena larga y muy larga y los plasmal\u00f3genos por cromatografia gas\/liquido en dicho tipo celular nos ha permitido demostrar su utilidad en el diagnostico de las enfermedades peroxisomales, mediante un unico procedimiento anal\u00edtico. asimismo, hemos demostrado su utilidad en el seguimiento bioqu\u00edmico de los pacientes con adrenoleucodistrofia ligada al cromosoma x(x-ald) bajo tratamiento, con glicerol trioleato\/glicerol trierucato(gto\/gte). Por otro lado, en el fenotipo adrenomieloneurop\u00e1tico (amn) de x-ald, las c\u00e9lulas mononucleares han presentado una menor acumulaci\u00f3n de 26:0, as\u00ed como una menor concentraci\u00f3n de 20:3w6 y mayor de 20:5w3 que los fenotipos cerebrales, a diferencia del suero\/plasma, en los que no se han observado diferencias entre los diferentes fenotipos en el perfil de \u00e1cidos grados. Estos resultados sugieren que la composici\u00f3n de los \u00e1cidos grasos en dicho tipo celular podr\u00eda estar ligada a la modulaci\u00f3n del proceso inflamatorio, dada la implicaci\u00f3n de las c\u00e9lulas mononucleares en la respuesta inflamatoria y la presencia de \u00e9sta en las formas cerebrales de la x-ald. Adem\u00e1s, hemos podido observar que la s\u00edntesis de \u00e1cidos grasos poliinsaturados de cadena larga derivados de los \u00e1cidos grasos poliinsaturados de cadena larga derivados de los \u00e1cidos grasos esenciales de las series w3 y w6 requiere, como pirmer caso, una elongaci\u00f3n y posteriormente, una    8-desaturaci\u00f3n, a difere<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Enfermedades peroxisomales: estudio en celulas mononucleares de metabolitos implicados en las vias metabolicas del peroxisoma.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Enfermedades peroxisomales: estudio en celulas mononucleares de metabolitos implicados en las vias metabolicas del peroxisoma. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Montserrat Ruiz Sales <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/07\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Giros Blasco M. Luisa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jordi Ordo\u00f1ez llanos <\/li>\n<li>m\u00c2\u00ba antonia Vilaseca busca (vocal)<\/li>\n<li>amparo Chabas bergon (vocal)<\/li>\n<li>jaume Coll cant\u00ed (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Montserrat Ruiz Sales El diagnostico bioqu\u00edmico de las enfermedades peroxiosomales se realiza, en primera instancia, a trav\u00e9s [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[11291,160,2148,940,17,3665],"tags":[172187,115752,172188,44520,64792,172186],"class_list":["post-80405","post","type-post","status-publish","format-standard","hentry","category-acidos-grasos","category-bioquimica","category-bioquimica-inmunologica","category-genetica-bioquimica","category-quimica","category-quimica-clinica","tag-amparo-chabas-bergon","tag-giros-blasco-m-luisa","tag-jaume-coll-canti","tag-jordi-ordonez-llanos","tag-mao-antonia-vilaseca-busca","tag-montserrat-ruiz-sales"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/80405","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=80405"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/80405\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=80405"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=80405"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=80405"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}