{"id":80420,"date":"2018-03-10T00:04:07","date_gmt":"2018-03-10T00:04:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacocinetico-y-toxicidad-de-la-csa-y-sus-metabolitos-en-trasplante-de-organos\/"},"modified":"2018-03-10T00:04:07","modified_gmt":"2018-03-10T00:04:07","slug":"estudio-farmacocinetico-y-toxicidad-de-la-csa-y-sus-metabolitos-en-trasplante-de-organos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-farmacocinetico-y-toxicidad-de-la-csa-y-sus-metabolitos-en-trasplante-de-organos\/","title":{"rendered":"Estudio farmacocinetico y toxicidad de la csa y sus metabolitos en trasplante de organos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Dolors Soy Muner <\/strong><\/h2>\n<p>La csa es un potente inmunodepresor que se emplea en el tratamiento de enfermedades autoinmunes y en la prevenci\u00f3n de rechaza en trasplante de \u00f3rganos.  el objetivo principal de esta memoria doctoral es evaluar la relaci\u00f3n entre toxicidad aguda y sus metabolitos primarios (am1, am4n), en pacientes con trasplante renal, hep\u00e1tico, renopacre\u00e1tico y de m\u00e9dula \u00f3sea. Para ello se puso a punto y se valid\u00f3 una met\u00f3dica anal\u00edtica por hplc, que permite separar y cuantificar la csa, csd, (ei), am1 y am4n. La determinaci\u00f3n de las muestras de sangre total de los pacientes estudiados, coincidentes en el tiempo con los episodios de rechazo o toxicidad (nefro, neuro o hepatotoxicidad), permiti\u00f3 observar que la contribuci\u00f3n de los metabolitos de la csa a la toxicidad es menor a la que se produce por el propio f\u00e1rmaco. La toxicidad es debida a la csa cuando \u00e9sta se encuentra a concentraciones sangu\u00edneas superiores a las consideradas como seguras, siendo la aportaci\u00f3n de los metabolitos muy escasa.  se plante\u00f3 como objetivo secundario, la detecci\u00f3n de interacciones farmacol\u00f3gicas que pudieran influir en la toxicidad,observ\u00e1ndose que la coadministraci\u00f3n de csa junto a inductores o inhibidores enzim\u00e1ticos podr\u00eda contribuir a los episodios de rechazo o toxicidad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacocinetico y toxicidad de la csa y sus metabolitos en trasplante de organos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacocinetico y toxicidad de la csa y sus metabolitos en trasplante de organos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Dolors Soy Muner <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/07\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mercedes Roca Massa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joaquin Giraldez deiro <\/li>\n<li>merce Brunet serra (vocal)<\/li>\n<li>carmen Lacasa diaz (vocal)<\/li>\n<li>josep Ribas sala (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Dolors Soy Muner La csa es un potente inmunodepresor que se emplea en el tratamiento de enfermedades [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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