{"id":80448,"date":"2018-03-10T00:04:11","date_gmt":"2018-03-10T00:04:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/validacion-de-un-metodo-de-determinacion-de-la-protea%c2%adna-transportadora-de-alta-afinidad-de-la-hormona-de-crecimientol-aplicacion-cla%c2%adnica\/"},"modified":"2018-03-10T00:04:11","modified_gmt":"2018-03-10T00:04:11","slug":"validacion-de-un-metodo-de-determinacion-de-la-protea%c2%adna-transportadora-de-alta-afinidad-de-la-hormona-de-crecimientol-aplicacion-cla%c2%adnica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/validacion-de-un-metodo-de-determinacion-de-la-protea%c2%adna-transportadora-de-alta-afinidad-de-la-hormona-de-crecimientol-aplicacion-cla%c2%adnica\/","title":{"rendered":"Validaci\u00f3n de un m\u00e9todo de determinaci\u00f3n de la prote\u00edna transportadora de alta afinidad de la hormona de crecimientol. aplicaci\u00f3n cl\u00ednica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Adela Casesnoves Ballester <\/strong><\/h2>\n<p>La prote\u00edna transportadora de la hormona de crecimiento de alta afinidad (ghbp) es una glucoprote\u00edna plasm\u00e1tica que se corresponde con el dominio extracelular del receptor de la hormona de crecimiento (gh). Una gran variedad de m\u00e9todos de uni\u00f3n han sido utilizados para su determinaci\u00f3n, \u00e9stos son muy laboriosos y adem\u00e1s pueden estar influenciados por las concentraciones de gh end\u00f3gena.  objetivos  desarrollar y validar m\u00e9todo inmunofuncional para determinar la ghbp de alta afinidad de forma r\u00e1pida, sencilla, precisa y espec\u00edfica.  material y m\u00e9todos  es un m\u00e9todo tipo sandwich en placa que mide la concentraci\u00f3n de ghbp de una muestra previamente saturada. Utiliza dos anticuerpos, un anti-ghbp monoclonal y un anti-gh policlonal de conejo que se unir\u00e1 al complejo ghbp-gh para establecer el s\u00e1ndwich. Un tercer anticuerpo anticonejo policlonal marcado con peroxidasaes el responsable de la se\u00f1al colorim\u00e9trica. Por tanto es un m\u00e9todo inmunol\u00f3gico por emplear anticuerpos y es funcioanl por valorar la capacidad de uni\u00f3n de la ghbp a la gh. Las muestras de suero eran obtenidas de 21 sujetos sano, 21 adultos con d\u00e9ficit de gh (basal y tras tratamiento conmgh) y 7 pacientes acromeg\u00e1licos (basal, 3 y 6 meses de tratamiento con lanre\u00f3tida de acci\u00f3n prolongada).  resultados  el m\u00e9todo posee una sensibilidad, exactitud y precisi\u00f3n aceptables y un intervalo de media adecuado (71 -4575 pmol\/l). Las concentraciones de ghbp fueron significativamente m\u00e1s bajas en los pacientes acromeg\u00e1licos que en el grupo control (615 +- 217 frente a 1105 + &#8211; 539 pmol\/l respectivamente, p&lt;0,01). Sin embargo no existerion diferencias significativas entre las concentraciones de ghbp en el grupo de adultos con d\u00e9ficil de gh y el grupo control (1248 + &#8211; 571 frente a 1105 + &#8211; 539 pmol\/l respectivamente). Las concentraciones de ghbp basales se correlacionaron positivamente con el \u00edndice de masa corporal (imc) en los sujetos sanos (p&lt;0,<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Validaci\u00f3n de un m\u00e9todo de determinaci\u00f3n de la prote\u00edna transportadora de alta afinidad de la hormona de crecimientol. aplicaci\u00f3n cl\u00ednica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Validaci\u00f3n de un m\u00e9todo de determinaci\u00f3n de la prote\u00edna transportadora de alta afinidad de la hormona de crecimientol. aplicaci\u00f3n cl\u00ednica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Adela Casesnoves Ballester <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/07\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Montserrat Mauri Dot<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Merino sanchez <\/li>\n<li>roser Casamitjana (vocal)<\/li>\n<li>anna Sanmart\u00ed (vocal)<\/li>\n<li>balbino Barcelo lucerna (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Adela Casesnoves Ballester La prote\u00edna transportadora de la hormona de crecimiento de alta afinidad (ghbp) es una 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