{"id":80489,"date":"2018-03-10T00:04:15","date_gmt":"2018-03-10T00:04:15","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-hipertension-renovascular-sobre-la-estructura-y-funcion-renal-en-ratas-diabeticas\/"},"modified":"2018-03-10T00:04:15","modified_gmt":"2018-03-10T00:04:15","slug":"efecto-de-la-hipertension-renovascular-sobre-la-estructura-y-funcion-renal-en-ratas-diabeticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-la-hipertension-renovascular-sobre-la-estructura-y-funcion-renal-en-ratas-diabeticas\/","title":{"rendered":"Efecto de la hipertensi\u00f3n renovascular sobre la estructura y funci\u00f3n renal en ratas diab\u00e9ticas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gallego Oviedo M. Belen <\/strong><\/h2>\n<p>Con el fin de separar los efectos debidos a cambios hemodin\u00e1micos de los cambios metab\u00f3licos t\u00edpicos de la diabetes, combinamos un modelo de hipertensi\u00f3n renovascular progresiva(coartaci\u00f3n de la aorta entre las dos arterias renales) con la diabetes inducida por estreptozotocina, y as\u00ed tenemos dos ri\u00f1ones sometidos a distinta presi\u00f3n de perfusi\u00f3n (pp) en el mismo en torno metab\u00f3lico. Los animales diab\u00e9ticos se dividieron en dos grupos: afectados(di-af), en los que aumenta la proteinuria del ri\u00f1\u00f3n hipertenso, y no afectados(di-naf), en los que no aumenta. Tanto el ri\u00f1\u00f3n situado por encima(de) como del situado por debajo (iz) de la ligadura, tres meses despu\u00e9s de la coartaci\u00f3n, se determinan: la filtraci\u00f3n glomerular, que es mayor en ambos ri\u00f1ones del grupo di-naf que en ambos ri\u00f1ones de los otros grupos; el flujo plasm\u00e1tico renal, similar en los ri\u00f1ones de los tres grupos; la pp, que es mayor en los ri\u00f1ones derechos que en los izquierdos; y la proteinuria, que es mayor en el ri\u00f1\u00f3n de que en el iz en los grupos coartaci\u00f3n y di-af, siendo mayor en \u00e9ste \u00faltimo. La fibrosis se cuantifica en secciones renales, te\u00f1idas con rojo sirio, por un sistema de an\u00e1lisis de imagen digital. Los ri\u00f1ones de e iz de los grupos diab\u00e9ticos muestran mayor \u00e1rea corpuscular y mesangial que los del grupo coartici\u00f3n, pero es el ri\u00f1\u00f3n de del grupo di-af el que presenta mayores valores de dichos par\u00e1metros. la valoraci\u00f3n semicuantitativa de tgf-b, observada por inmunohistoqu\u00edmica revela que la expresi\u00f3n glomerular mayor se encuentra en el ri\u00f1\u00f3n derecho del grupo di-af y la menor en el ri\u00f1\u00f3n izquierdo del grupo coartici\u00f3n. estos resultados demuestran que la hipertensi\u00f3n glomerular y la hiperglucemia act\u00faan de forma sin\u00e9rgica en la alteraci\u00f3n de la estructura y funci\u00f3n renal y que el tgf-b est\u00e1 implicado en dicha alteraci\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la hipertensi\u00f3n renovascular sobre la estructura y funci\u00f3n renal en ratas diab\u00e9ticas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la hipertensi\u00f3n renovascular sobre la estructura y funci\u00f3n renal en ratas diab\u00e9ticas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gallego Oviedo M. Belen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/07\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Miguel Lopez Novoa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alejandro Esteller  perez <\/li>\n<li>raimundo Garcia del moral (vocal)<\/li>\n<li>tomas Quesada perez (vocal)<\/li>\n<li> Arevalo gomez Miguel angel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gallego Oviedo M. Belen Con el fin de separar los efectos debidos a cambios hemodin\u00e1micos de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,9,675,730,139,179,156,1323,9386,226],"tags":[9693,9184,172320,5695,22628,24894],"class_list":["post-80489","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-ciencias-medicas","category-fisiologia-animal","category-histologia-animal","category-medicina-interna","category-nefrologia","category-patologia","category-patologia-experimental","category-salamanca","category-zoologia","tag-alejandro-esteller-perez","tag-arevalo-gomez-miguel-angel","tag-gallego-oviedo-m-belen","tag-jose-miguel-lopez-novoa","tag-raimundo-garcia-del-moral","tag-tomas-quesada-perez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/80489","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=80489"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/80489\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=80489"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=80489"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=80489"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}