{"id":80503,"date":"2018-03-10T00:04:15","date_gmt":"2018-03-10T00:04:15","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-sobre-la-regulacion-de-la-secrecion-de-insulina-inducida-por-nutrientes-propiedades-del-sensor-de-ca2-y-de-la-insulina-zn-2\/"},"modified":"2018-03-10T00:04:15","modified_gmt":"2018-03-10T00:04:15","slug":"estudios-sobre-la-regulacion-de-la-secrecion-de-insulina-inducida-por-nutrientes-propiedades-del-sensor-de-ca2-y-de-la-insulina-zn-2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudios-sobre-la-regulacion-de-la-secrecion-de-insulina-inducida-por-nutrientes-propiedades-del-sensor-de-ca2-y-de-la-insulina-zn-2\/","title":{"rendered":"Estudios sobre la regulaci\u00f3n de la secreci\u00f3n de insulina inducida por nutrientes: propiedades del sensor de ca2+ y de la insulina-zn 2+"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gonz\u00e1lez Vertusa Jos\u00e9 Agust\u00edn <\/strong><\/h2>\n<p>1,- en presencia de amino\u00e1cidos a concentraciones encontradas en el plasma de ratones alimentados ad libitum se observ\u00f3 un desplazamiento significativo de la curva dosis\/respuesta de glucosa hacia la izquierda, los amino\u00e1cidos a estas concentraciones podr\u00edan estar facilitando la labor de la c\u00e9lula beta como sensor de glucosa.  2,- con el objetivo de analizar como es la se\u00f1al de ca2+ que dispara la exocitosis en c\u00e9lula beta se utilizaron varios quelantes de ca2+ intracelular con diferentes propieades cin\u00e9ticas (egta, bapta, calcium-orange 5n, calcium-green 5n, calcium-green 1 y calcium-green 2). Los resultados sugieren que la entrada de ca2+ extracelular es una se\u00f1al r\u00e1pida y localizada.  3,- la alb\u00famina facilit\u00f3 la desintegraci\u00f3n del hex\u00e1mero de insulina a monomeros gracias a su capacidad para quelar zn2+. Probablemente, esta prote\u00edna es necesaria \u00abin vivo\u00bb para transformar el pol\u00edmero de insulina en su forma activa monom\u00e9rica una vez haya sido secretada.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios sobre la regulaci\u00f3n de la secreci\u00f3n de insulina inducida por nutrientes: propiedades del sensor de ca2+ y de la insulina-zn 2+<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios sobre la regulaci\u00f3n de la secreci\u00f3n de insulina inducida por nutrientes: propiedades del sensor de ca2+ y de la insulina-zn 2+ <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gonz\u00e1lez Vertusa Jos\u00e9 Agust\u00edn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/07\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Bernat Soria Escoms<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  vicente Sanchez andres <\/li>\n<li>Francisco Bedoya bergua (vocal)<\/li>\n<li>Mar\u00eda etelvina Andreu s\u00e1nchez (vocal)<\/li>\n<li>eduard Monta\u00f1a mias (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonz\u00e1lez Vertusa Jos\u00e9 Agust\u00edn 1,- en presencia de amino\u00e1cidos a concentraciones encontradas en el plasma de ratones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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