{"id":80554,"date":"1999-07-09T00:00:00","date_gmt":"1999-07-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/actividad-antihipertensiva-y-mecanismo-de-accion-de-p-4-y-p-13\/"},"modified":"1999-07-09T00:00:00","modified_gmt":"1999-07-09T00:00:00","slug":"actividad-antihipertensiva-y-mecanismo-de-accion-de-p-4-y-p-13","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/actividad-antihipertensiva-y-mecanismo-de-accion-de-p-4-y-p-13\/","title":{"rendered":"Actividad antihipertensiva y mecanismo de accion de p-4 y p-13"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Velasco Villar Antonio  Javier <\/strong><\/h2>\n<p>La hipertensi\u00f3n es un proceso en que existe una elevaci\u00f3n cr\u00f3nica de la presi\u00f3n sit\u00f3lica y\/o diast\u00f3lica. El tratamiento de la hipertensi\u00f3n arterial inicialmente debe constar de una serie de medidas no farmacol\u00f3gicas, pero si con este tratamiento no se consiguen normalizar los valores de presi\u00f3n arterial, adem\u00e1s de continuar con estas medidas se pueden utilizar f\u00e1rmacos antihipertensivos. Los antagonistas de calcio son muy usados como f\u00e1rmacos antihipertensivos.  en este trabajo hemos evaluado la actividad antihipertensiva a largo plazo de varios compuestos sint\u00e9ticos y los hemos comparado con nifedipino, siendo p-4 y p-13 los m\u00e1s interesantes. Estos experimentos se han realizado en ratas shr.  estos dos compuestos presentan un efecto antihipertensivo inespec\u00edfico por interactuar con el sistema adrenergico. Con el sistema renina angiotensina aldosterona y con el oxido n\u00edtrico. Adem\u00e1s se metabolizan en otros compuestos con cierta actividad antagonista de calcio, que hacen que las acciones de p-4 y de p-13 sean m\u00e1s duraderas que las producidas por las dos dihidropiridinas de referencia, nifedipino y nitrendipino. Estos experimentos se han realizado en ratas normotensas descerebradas y desmeduladas.  p-4 y p-13 aumentan el flujo sangu\u00edneo renal y mesent\u00e9rico y disminuyen la resistencia vascular renal y mes\u00e9ntrica, adem\u00e1s p-13 disminuye tambi\u00e9n la resistencia vascular en la arteria car\u00f3tida. Todas estas acciones vasodilatadoras contribuyen el efecto antihipertensivo de estos compuestos. Estos experimentos se han realizado en ratas normotensas anestesiadas con uretano y diazepam.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Actividad antihipertensiva y mecanismo de accion de p-4 y p-13<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Actividad antihipertensiva y mecanismo de accion de p-4 y p-13 <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Velasco Villar Antonio  Javier <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/09\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis San Rom\u00e1n Del Barrio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: felipe Sanchez de la cuesta  alarcon <\/li>\n<li>esther Caballero salvador (vocal)<\/li>\n<li>Juan a Benedi gonzalez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Velasco Villar Antonio Javier La hipertensi\u00f3n es un proceso en que existe una elevaci\u00f3n cr\u00f3nica de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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