{"id":8063,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/accion-de-agonistas-purinergicos-sobre-la-secrecion-de-acido-en-celulas-parietales-aisladas-de-mucosa-gastrica-de-conejo\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"accion-de-agonistas-purinergicos-sobre-la-secrecion-de-acido-en-celulas-parietales-aisladas-de-mucosa-gastrica-de-conejo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/accion-de-agonistas-purinergicos-sobre-la-secrecion-de-acido-en-celulas-parietales-aisladas-de-mucosa-gastrica-de-conejo\/","title":{"rendered":"Accion de agonistas purinergicos sobre la secrecion de acido en celulas parietales aisladas de mucosa gastrica de conejo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Salgado Gorostizaga <\/strong><\/h2>\n<p>Los nucleosidos y nucleotidos de adenina ejercen potentes acciones extracelulares en un amplio rango de sistemas fisiologicos incluido el tracto gastrointestinal. La mayor parte de estas acciones son medidas por receptores purinergicos habiendose sugerido que la adenosina actua sobre purinoceptores p1 mientras que el atp lo hace sobre purinoceptores p2. Puesto que la informacion relativa al efecto de las purinas sobre secreciones digestivas es escasa y controvertida, el presente trabajo aborda el estudio de los efectos y posibles vias de accion de la adenosina y sus analogos estructurales 2-cado y neca, metabolicamente mas estables, sobre la secrecion gastrica de acido.  en la experimentacion se ha empleado una fraccion rica en celulas parietales de mucosa gastrica de conejo, aisladas segun el metodo de fryklund (biochem.  pharmacol., 33:273-280, 1984) y enriquecidas mediante elutriacion centrifuga siguiendo el protocolo de separacion descrito por sanders y soll (meth. Enzymol., 171: 482-497, 1989), efectuandose dos tipos de estudios:  1) sobre celulas paritales no estimuladas y 2) estimuladas con histamina, dibutiril-ampc y carbacol.  el analisis de los resultados obtenidos -ausencia de efecto de la cimetidina, orden de potencia agonista, valores de ka \u00abaparente\u00bb y accion antagonista de la teofilina -sugiere que el efecto estimulador de la produccion de acido no es mediado, directamente o indirectamente, por receptores h2 de histamina, y presumiblemente, tiene lugar a traves de receptores p1 subtipo a2b, localizados en las celulas parietales cuya ocupacion promueve la activacion de la adenilato ciclasa con el consiguiente aumento del nivel de ampc y estimulacion concomitante de la secrecion gastrica de acido en conejos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Accion de agonistas purinergicos sobre la secrecion de acido en celulas parietales aisladas de mucosa gastrica de conejo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Accion de agonistas purinergicos sobre la secrecion de acido en celulas parietales aisladas de mucosa gastrica de conejo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Salgado Gorostizaga <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Ainz Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Gandarias Y Bajon Juan  Manuel <\/li>\n<li>Manuel Ramirez Sanchez (vocal)<\/li>\n<li> Iriarte Ezcurdia Jos\u00e9 Antonio (vocal)<\/li>\n<li>M\u00aa Concepci\u00f3n Iribar Ibabe (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Salgado Gorostizaga Los nucleosidos y nucleotidos de adenina ejercen potentes acciones extracelulares en un amplio rango [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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